Parkinson’s Disease  – MPTP Mouse Model of Parkinson’s Disease

Target dopaminergic cell loss in the inducible MPTP Mouse Model of Parkinson’s Disease

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MPTP Mouse Model of Parkinson’s Disease Characteristics

Parkinson’s disease (PD) is a neurodegenerative disorder that affects the motor systems in early stages, leading to symptoms such as trembling, slowing of movement, and muscle stiffness. The distinct disease mechanism can be modelled in different mouse models of PD. Degeneration of dopaminergic cells in the substantia nigra (SN) is the primary cause of the motor symptoms in PD. Administration of the MPTP, a pro-drug for the neurotoxin MPP+, selectively induces dopaminergic cell toxicity in the SN, representing one of the most widely used mouse PD models.

InnoSer offers unique services using several inducible in vivo PD models, including MPTP-based PD models. In-house validation experiments show that MPTP-induced PD models show loss of dopaminergic SN neurons, motor impairment, and activation of the NLRP3 inflammasome. As different MPTP dosing regimens lead to distinct neurodegenerative phenotypes; the choice of the model depends on your experimental compound’s hypothesized mechanism of action and research goals. 

✓ Acute and (sub)chronic varying dosing regimens possible, leading to distinct phenotypes.

✓  Dopaminergic neuronal loss documented in the SN.

✓  Motor impairments.

✓  Neuroinflammation (e.g., NLRP3 inflammasome activation).

✓  Suitable for testing anti-neuroinflammatory and neuroprotective compounds.

European based preclinical CRO offering Infantile Epileptic Encaphalopathy Stxbp1 mouse models for drug development

Take advantage of InnoSer’s expertise, flexibility and collaborative approach for your research. Our in-house neurology experts have long standing experience with modelling PD in vivo and are help guide your decision on choosing the best model fit for your current research goals. 

InnoSer’s neurology expert team possesses relevant experience in working with multiple therapy types ranging from small molecules, peptides, enzymes, oligonucleotides, gene therapy (viral vectors – e.g.. AAVs) and immunotherapies (antibody/vaccine immunotherapies). 

Your Neurology Research Starts Here.

Choose the Right Model for Your Research with Confidence

Belgian based preclinical neurology CRO mouse models

MPTP Mouse Model of Parkinson’s Disease Sample Data

MPTP Mouse Model of Parkinson’s Disease Readouts

Key Behavioral Readouts in the MPTP Mouse Model

Biological Readouts

Test the efficacy of your treatments with the following biological readouts: 
  
  • (Digital) histopathology 
  • Immunohistochemistry (dopamine neurons, neuroinflammation) 
  • Immunofluorescence and FISH

    The People Behind Your Research

    Thomas Vogels, PhD Neurology study director InnoSer

    Thomas Vogels, PhD, In Vivo Neurology Study Director

    Leads an expert team of scientists with vast experience in our Neurology models to help you choose the right model and guide your optimal study design. We provide the solution to accelerating your drug development.

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