Cardiovascular disease modelsAngiotensin IIinduced Hypertension Mouse Model

Test efficacy of novel treatments against hypertension and hypertension-associated kidney injury using the Angiotensin II-Induced Hypertension Mouse Model

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Angiotensin II-induced Hypertension Mouse Model Characteristics

Angiotensin II-induced hypertension mouse model is the most widely used translational model of progressive hypertensive cardiac remodeling, left ventricular dysfunction and cardiac fibrosis induced by chronic Angiotensin II (AngII) infusion.  Chronic infusion of AngII, an endocrine hormone within the renin-angiotensin-aldosterone system (RAS), promotes vasoconstriction, cellular proliferation, hypertrophy, and fibrosis, leading to sustained hypertension, cardiac hypertrophy, and ultimately results in heart failure.  

The chronic hypertension mouse model closely mirrors human hypertensive heart disease, making it a highly translationally relevant research model for testing interventions aimed at reducing hypertension-driven cardiac remodeling and hypertension-induced heart failure. Due to the effects of AngII infusion on systemic blood pressure, this model is also suitable for studying hypertension-induced kidney injury and evaluating therapies for renal complications associated with chronic hypertension.  

✓  The model is relevant for hypertension-induced cardiovascular dysfunction and related heart failure, as well as kidney injury.  

Angiotensin II

Take advantage of InnoSer’s combined expertise in cardiovascular diseases and in-house nephrology capabilities to obtain robust efficacy data of your compound in managing hypertension-associated cardiac failure and kidney disease. Contact us today to discuss how this model can support your research objectives in hypertension, cardiac fibrosis, hypertension-induced kidney injury, and heart failure.  

Angiotensin IIinduced Hypertension Mouse Model Sample Data

Angiotensin IIinduced Hypertension Mouse Model Readouts

Key Hypertension mouse model readouts that InnoSer offers


Test the efficacy of your treatments in the following battery of translational readouts:
    • Echocardiography
    • Heart remodeling & fibrosis
    • Hypertrophy
    • Kidney function (GFR)
    • Blood urea nitrogen
    • Histopathology  

    The People Behind Your Research

    Yanick Fanton, PhD, Chief Scientific Officer

    As Chief Science Officer at InnoSer, Yanick is responsible for all customer studies at InnoSer and takes care of the scientific and technical coordination.

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