Alpha-synuclein seeding models

Recapitulate the key structural features and spreading of alpha-synuclein aggregates found in the brain of Parkinson’s disease and other synucleinopathy patients

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Parkinson’s disease (PD) is a neurodegenerative disorder that affects the motor systems in early stages, leading to symptoms such as trembling, slowing of movement, and muscle stiffness. The distinct disease mechanism can be modelled in different mouse models of PD. 

Alpha-synuclein (α-syn) inclusions are the main histopathological hallmark correlating with clinical symptoms of not only PD, but also other synucleinopathies such as dementia with Lewy bodies (DLB), and multiple systems atrophy (MSA). In line, the development and spread of α-syn aggregates plays a key role in the disease pathophysiology.

InnoSer has extensive preclinical experience with α-syn seeding using both PD patient-derived brain extracts and recombinant seeds.  Injection of brain extracts from these diseases in the brain of mice closely mimics the structural features of the α-syn aggregates found in patients and allows studying of α-syn spreading as a therapeutic readout. The choice of a specific α-syn seeding model i.e., the brain source or recombinant seed depends on the synucleinopathy of interest.   

Take advantage of InnoSer’s expertise in modelling α-syn pathology, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with modelling α-syn pathology in vivo and are happy to help guide your decision on study design fit for your current research goals. 

Alpha-synuclein seeding models that InnoSer offers:

  • α-syn aggregates can be injected in both wild-type (WT) or transgenic mice.
  • Both recombinant and patient-derived seeds are available.

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Belgian based preclinical neurology CRO mouse models

Key readouts

Test the efficacy of your treatments in the following battery of cognitive behavioural tests:

Test the efficacy of your treatments with the following biological readouts:
  • Immunohistochemistry (e.g., phospho-α-syn, neurodegeneration) 
  • Immunofluorescence (e.g., α-syn aggregates, neuroinflammation)

Related Parkinson’s Disease model options

MPTP Induced PD Models

InnoSer offers unique services using MPTP-based inducible PD models.

Transgenic Alpha-Synuclein Models

InnoSer offers fee-for-service transgenic α-syn mouse models.

Seeding Alpha-Synuclein Models

InnoSer has extensive experience with α-syn seeding using both PD patient-derived brain extracts and recombinant seeds.

AAALAC Accreditation

InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.


Animal Welfare

The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why Innoser has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.

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