Alpha-synuclein seeding models

Recapitulate the key structural features and spreading of alpha-synuclein aggregates found in the brain of Parkinson’s disease and other synucleinopathy patients

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Home » Neurology Research Models and Services  » Parkinson’s models and services » Parkinson’s models – Alpha-synuclein seeding models
Parkinson’s disease (PD) is a neurodegenerative disorder that affects the motor systems in early stages, leading to symptoms such as trembling, slowing of movement, and muscle stiffness. The distinct disease mechanism can be modelled in different mouse models of PD. 

Alpha-synuclein (α-syn) inclusions are the main histopathological hallmark correlating with clinical symptoms of not only PD, but also other synucleinopathies such as dementia with Lewy bodies (DLB), and multiple systems atrophy (MSA). In line, the development and spread of α-syn aggregates plays a key role in the disease pathophysiology.

InnoSer has extensive preclinical experience with α-syn seeding using both PD patient-derived brain extracts and recombinant seeds.  Injection of brain extracts from these diseases in the brain of mice closely mimics the structural features of the α-syn aggregates found in patients and allows studying of α-syn spreading as a therapeutic readout. The choice of a specific α-syn seeding model i.e., the brain source or recombinant seed depends on the synucleinopathy of interest.   

Take advantage of InnoSer’s expertise in modelling α-syn pathology, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with modelling α-syn pathology in vivo and are happy to help guide your decision on study design fit for your current research goals. 

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Alpha-synuclein seeding models that InnoSer offers:

  • α-syn aggregates can be injected in both wild-type (WT) or transgenic mice.
  • Both recombinant and patient-derived seeds are available.

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Compare our model capabilities and discover which of our neurology platforms suits your research needs

Neurology platform overview
Belgian based preclinical neurology CRO mouse models

Key readouts

Test the efficacy of your treatments in the following battery of cognitive behavioural tests:

Behavioural tests catalogue
Test the efficacy of your treatments with the following biological readouts:
  • Immunohistochemistry (e.g., phospho-α-syn, neurodegeneration) 
  • Immunofluorescence (e.g., α-syn aggregates, neuroinflammation)

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Seeding Alpha-Synuclein Models

InnoSer has extensive experience with α-syn seeding using both PD patient-derived brain extracts and recombinant seeds.
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