The Grip Strength test measures the maximum force a rodent can exert when pulling on a specialized grip bar. During the Grip Strength test, the neuromuscular function of a mouse is assessed by measuring the peak force a mouse applies by grasping a bar connected to a force meter. A rodent (mouse or rat) instinctively grasps the bar, and the force required to detach the animal from the grip is recorded as a measure of its muscle strength. Five trials with front paws are followed by five trials with both the front and hind paws combined. Accordingly, the median of these five trials is used as a measure of grip strength. Therefore, the results provide clear, quantitative data on grip force, which is a direct indicator of neuromuscular integrity.

This test is a fast, simple, and highly reproducible method for evaluating muscle strength and neuromuscular function in rodents. It provides critical, quantitative data that are essential for studying muscular weakness, motor function impairments, and therapeutic efficacy in preclinical models. As part of InnoSer’s innovative preclinical neurology CRO solutions, this motor function test is commonly used in combination with several other motor tests, such as Balance Beam test, Rotatod, or CatWalk automated gait analysis system. However, as each motor function test is unique, targeting different motor function skills in rodents, we recommend you discuss the most appropriate motor function behavioral test battery with our neurology study directors.