Multiple Sclerosis Mouse Models
Test novel compounds targeting Multiple Sclerosis with the support of our services in de- and re-myelinating multiple sclerosis mouse models
Multiple sclerosis (MS) is the most common chronic inflammatory, demyelinating, and neurodegenerative disease. The pathological hallmark of MS is the formation of demyelinating lesions in the brain and spinal cord. The core neuropathology of MS is the loss of oligodendrocytes and myelin sheaths, leading to axonal damage and neuroinflammation.
InnoSer offers unique preclinical contract research services using several multiple sclerosis mouse models that show pathoogical de- and re-myelienation. In the Cuprizone mouse model of multiple sclerosis, Cuprizone induces oligodendrocyte death and reversible myelienation, recapitulating the pathophysiology of human MS. However, in the Cuprizone/ Rapamycin mouse model of multiple sclerosis, the addition of the mTOR inhibitor, Rapamycin, prevents spontaneous re-myelienation by newly differentiated oligodendrocytes, thereby creating a more severe demyelienating phenotype.
Take advantage of InnoSer’s expertise, flexibility and collaborative approach for your research. We support our clients in identifying new drugs or applications, characterizing their pharmacological properties, and conducting safety and efficacy testing with state-of-the-art readout capabilities and histopathological analysis.
Multiple sclerosis mouse models that InnoSer offers:
- Cuprizone model (de- and remyelination).
- Cuprizone + rapamycin model (demyelination).
Find the right model for you.
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Key readouts in the Multiple Sclerosis mouse models
Test the efficacy of your treatments with the following commonly used behavioral tests:
- IHC: Myelin, immune response, astrocytes, de/remyelination (MBP, PLP), Inflammation (macrophages, T- and B-cells, microglia, astrocytes)
- mRNA or protein of inflammatory mediators, receptors, etc.
Example data featuring InnoSer’s Multiple Sclerosis mouse models
Cuprizone-treated mice show reductions in overall activity by measuring the distance moved in PhenoTyper™ cages
Spontaneous behaviour of mice in the automated home-cage (PhenoTyper™) is tracked at high resolution and analysed by AHCODA. Highly discriminative parameters are produced, detecting changes in domains of motor function, circadian rhythm and others.
Related rare disease model options
Neurology Platform Overview
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Vanishing White Matter (eIF2B) Mouse Models
InnoSer offers unique services with an Eif2b4 / Eif2b5 mouse model of vanishing white matter (VWM).
AAALAC Accreditation
InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
Animal Welfare
The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why Innoser has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.
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