Digital Histopathology

Molecular and morphological analysis of your preclinical samples.

Pathological assessment of samples from cell cultures to organoids and to animal models is a critical step of preclinical drug development. Effective assessments of toxicology and efficacy of compounds support their development towards treating human diseases. InnoSer offers pathology services via a close partnership with its sister company Connected-Pathology.

 

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Whole slide imaging: deeper and more accurate analyses

Flexible timelines

Automated and fast tissue processing

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AI-assisted pathology assessment and scoring

Processing large volume studies

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Routine and customized staining and assay development

cystic index algorithm applied for kidney disease analysis

Pathology driven by smart technologies

Your samples are processed with the latest technologies for specimen selection and qualification, embedding, slide preparation and a broad catalogue of highly standardized chemical or immuno chemical staining for bright field or fluorescent evaluation. Digitized and automated workflows ensure fast, cost effective, and easy to scale up solutions. We utilise smart examination tools to provide accurate, fast and efficient results for our clients.  Our sister company Connected-Pathology is continuously working on expanding their applicable smart algorithms. Our ADPKD studies have already greatly benefited from their cystic indexing algorithm in providing reliable, quick and quantitative results.

Deeper insights to your preclinical research

A variety of pathological assessment methods can be brought together and customized for your project needs. From traditional staining methods for gross examination of tissues to state-of-the-art NGS and mass spectrometry for molecular and cellular analyses, we offer interdisciplinary approaches to answer your preclinical questions. These include:

  • Conventional histology: H&E
  • Immunochemical stains
  • Immunohistochemistry
  • Immunofluorescence
  • Cytology & molecular pathology
  • Digital pathology and quantitative analysis
  • Automated track and trace of samples
  • Long term cloud storage of raw data

 

Please get in touch with us and let’s dicuss which methods will be valuable for moving your compounds further in the preclincal development process.

Neurology research applications

A variety of pathological assessment methods can be brought together and customized for your project needs. From traditional staining methods for gross examination of tissues to state-of-the-art NGS and mass spectrometry for molecular and cellular analyses, we offer interdisciplinary approaches to answer your preclinical questions. These include:

  • Histopathologic evaluation and morphologic analysis of animal models of neurologic disease e.g. AD, PD, CMT, ALS etc,.. 
  • Immunophenotyping of immune cell infiltration: using IHC and IF, we can detect different subsets of immune cells (e.g. CD3, CD4, CD8, CD20, CD68, PAX5). 
  • Neuroinflammation: Morphologic and immunohistological evaluation of neuroinflammation (e.g. GFAP for gliosis/astrocytosis) 
  • IHC markers for pathologic aggregates in AD, PD, ALS etc. with proven experience with p-Tau, P-alpha-syn and TDP-43 pathology and IHC markers in human samples and animal models. 
  • Amyloid aggregate visualization, characterization and quantification; Methoxy-X04, Congo red, etc,. 
  • Myelination evaluation in de-myelinating conditions (e.g. CMT). 
  • Neuromuscular Junction (NMJ) pathology: pathologic evaluation of pre- and post-synaptic vesicles (e.g. Neurofilaments (NF), SYT-2) 
  • Histologic evaluation of muscular dystrophies with neurogenic origins; DMD.  
  • Assessment of apoptosis using anti Caspase-3 antibodies and TUNEL assay. 
  • Customized assay developments based on client’s study goal and needs. 

 

Please get in touch with us and let’s dicuss which methods will be valuable for moving your compounds further in the preclincal development process.

Explore the full range of possibilities

Questions about how our services can accelerate your research? Reach out to one of our experts today and we can provide you with tailored advice on getting started