3R’s: Replacement, Reduction, Refinement
Replace
With alternatives where ever possible
Reduce
The number of animals used
Refine
Experiments to minimize impact on animals
In vivo testing has been a valuable part of drug development and of the global fight against countless diseases. Now, thanks to innovative technologies, we are able to facilitate alternatives to animal experimentation and offer human specific preclinical research. At InnoSer, we also constantly re-evaluate and improve our protocols, ensure strict adherence to them, and remain transparent in our communication about these methods.
InnoSer’s 3R approach
In vitro models as alternatives
InnoSer strongly invests in a service portfolio of in vitro assays based on organoids and research and development programs such as organ-on-chip technology. Increasing the reliability of alternative preclinical screening models can not only promise the highest translation to clinical studies, but also reduce the number of animals needed.
Efficient colony management
InnoSer’s quality standards ensure efficient breeding of genetically altered rodents and facilitates the exchange of animals between institutes without the need for rederivation, both contributing to the reduction in number of animals. We also provide cryopreservation of rodent lines to decrease the need of rebreeding.
In vivo imaging for early decision making
Especially in long term studies, in vivo imaging proves to be extremely valuable in early determination of compound effectiveness. For example, in some of our oncology or PKD models, we can acquire mid-study data by non-invasive and real-time imaging. Based on the data we can focus only on a subset of lead compounds. This not only helps us refine animal use, but also manage our customer’s budget efficiently by cutting unnecessary costs.
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AAALAC Accreditation
InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
Animal Welfare
The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why Innoser has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.
Related Resources
Opportunity to connect with preclinical offerings at Knowledge for Growth
Our commitment to the 3R's: How the 3R's shape animal research
Introducing InnoSer's Acceleration Program (ISAP)
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