Lead Optimization
We optimize your lead compounds using expertise and data-driven decisions
The lead optimization stage marks the end of the drug discovery phase and the start of pharmaceutical or biological development. Insight into the absorption, distribution, metabolism, and excretion (ADME) is key to progressing your identified lead compounds after the hit to lead phase.
We support you in the further investigation of their target specificity, pharmacokinetic properties, bioavailability, and safety profiles by offering relevant in vitro and in vivo models, cost-efficient methods, and a key selection of assays using data-driven decision making.
Our Approach
We operate as a unified, committed, accessible team in solving your challenges quickly
Our study directors and technical specialists support you in the selection of your lead compounds with proof of effectiveness, decreased toxicity and absorption properties.
Making use of our portfolio of in vitro and in vivo models combined with in-depth and robust readouts from our state-of-the-art biomarker and imaging equipment, we can apply a data-driven and risk-based approach to this stage of your compound development.
Our team of experts consider your entire development journey when recommending cost-efficient solutions to reach your research milestones. We leverage our network of specialists to reduce your timeline and progress your compound more effectively to the patients that need it most.
Partner with an Expert to Advance Your Therapeutic Discovery.
Work with our team to evaluate your drug and target for therapeutic effects with precision and expertise
Lead Optimization Techniques
InnoSer has experienced and dedicated study directors that manage and guide a proactive and effective study design along with a team of associates and bio technicians to help achieve high-quality service and results. With in-depth knowledge of our models and areas of therapeutic expertise we streamline the selection process to ensure robust results and fast progression. With our in vitro and in vivo facilities, we can support ADME and custom studies with the assessment of lead drug metabolites and relevant biomarkers. Through qualified partners we also offer pharmacometric assessment of lead-compounds. By estimating clinical pharmacokinetics, in-silico, early on in drug development this helps to assess clinical feasibility and reduce risk in your pipeline
We provide the following crucial services that are specific to the progression of your compound into the preclinical phase.
In Vivo Pharmacology
- Early assessment of DMPK properties
- Efficacy
- PK feasibility
- Metabolic stability
- Proof-of-Concept Studies
- MTD (Maximum Tolerated Dose) determination
- Dose frequency
- Dose response relations
- Therapeutic efficacy in in vivo disease model
In Vivo DMPK
- Assess route of administration
- Bioavailability
- Drug distribution
- DRF (Dose Range Finding)
- Preclinical efficacy
Toxicology
- Single Dose Toxicity
- Repeated Dose Toxicity
- Toxicokinetics
Biomarker Assessment
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Custom assay development and validation
- Meso Scale Discovery
- ELISA
- IHC
- Flow Cytometry
- High Content Imaging
Imaging capabilities:
With our state-of-the-art equipment we can perform high content cellular imaging which supports compound prioritization and timely decision-making during the hit to lead and lead optimization phases of the drug development project.
Flow cytometry gives us the ability to analyze heterogeneous cell populations at specific time points making it a useful tool for testing drug-cell interactions.
Partnering with us will give you access to Meso Scale Discovery (MSD) testing services ideal for immunogenicity testing and multiplex biomarker assays
Navigate The Drug Development Pipeline
AAALAC Accreditation
InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
Animal Welfare
The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why InnoSer has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.
info@innoserlaboratories.com