We optimize your lead compounds using expertise and data-driven decisions
The lead optimization stage marks the end of the drug discovery phase and the start of pharmaceutical or biological development. Insight into the absorption, distribution, metabolism, and excretion (ADME) is key to progressing your identified lead compounds after the hit to lead phase.
We support you in the further investigation of their target specificity, pharmacokinetic properties, bioavailability, and safety profiles by offering relevant in vitro and in vivo models, cost-efficient methods, and a key selection of assays using data-driven decision making.
We operate as a unified, committed, accessible team in solving your challenges quickly
Our study directors and technical specialists support you in the selection of your lead compounds with proof of effectiveness, decreased toxicity and absorption properties.
Making use of our portfolio of in vitro and in vivo models combined with in-depth and robust readouts from our state-of-the-art biomarker and imaging equipment, we can apply a data-driven and risk-based approach to this stage of your compound development.
Our team of experts consider your entire development journey when recommending cost-efficient solutions to reach your research milestones. We leverage our network of specialists to reduce your timeline and progress your compound more effectively to the patients that need it most.
Contact an expert and let’s advance your lead compounds
We provide the following crucial services that are specific to the progression of your compound into the preclinical phase.
In Vivo Pharmacology
- Early assessment of DMPK properties
- PK feasibility
- Metabolic stability
- Proof-of-Concept Studies
- MTD (Maximum Tolerated Dose) determination
- Dose frequency
- Dose response relations
- Therapeutic efficacy in in vivo disease model
In Vivo DMPK
- Assess route of administration
- Drug distribution
- DRF (Dose Range Finding)
- Preclinical efficacy
- Single Dose Toxicity
- Repeated Dose Toxicity
Custom assay development and validation
- Meso Scale Discovery
- Flow Cytometry
- High Content Imaging
With our state-of-the-art equipment we can perform high content cellular imaging which supports compound prioritization and timely decision-making during the hit to lead and lead optimization phases of the drug development project.
Flow cytometry gives us the ability to analyze heterogeneous cell populations at specific time points making it a useful tool for testing drug-cell interactions.
Partnering with us will give you access to Meso Scale Discovery (MSD) testing services ideal for immunogenicity testing and multiplex biomarker assays