Cardiovascular disease models – Transverse Aortic Constriction (TAC) Mouse Model of Heart Failure
Test efficacy of novel heart failure treatments using the golden standard TAC Mouse Model
TAC Mouse Model Characteristics
The transverse aortic constriction (TAC) mouse model is a surgical model of pressure overload-induced cardiac hypertrophy and associated heart failure. TAC is a surgical procedure which constricts a targeted region of the aortic arch, simulating pressure overload seen in human conditions like aortic stenosis. TAC surgery induces initial compensation hypertrophy, associated with temporary enhancement of cardiac contractility, followed by progressive left ventricular dilation and hypertrophy, resulting in eventual heart failure. This progression allows for the study of both Heart Failure with Reduced Ejection Fraction (HFrEF) and Heart Failure with Preserved Ejection Fraction (HFpEF).
Recognized as the gold standard in preclinical cardiac research, the gradual and reproducible development of cardiac hypertrophy in the TAC mouse model facilitates longitudinal studies, making it an ideal model for assessing drug efficacy in heart failure interventions. InnoSer’s skilled surgical team conducts TAC procedures with high precision and expertise, ensuring consistent and reproducible outcomes for your research. Contact our expert team today to discuss how the TAC mouse model can support your preclinical research into heart failure interventions.
✓ Gold-standard surgical mouse model of cardiac hypertrophy and associated heart failure.
✓ TAC leads to left ventricular dilation and hypertrophy.
✓ Model can be used to study both HFrEF and HFpEF.

As a preclinical cardiovascular CRO, InnoSer works with multiple validated research models of common cardiovascular diseases. To study hypertension-associated cardiovascular dysfunction and heart failure, InnoSer offers Angiotensin II-induced hypertension mouse model.
InnoSer’s specialised facilities and trained personnel equipped for reliable execution of technical cardiac surgeries and other functional procedures allows for possibility to run studies using models of myocardial infarction using LAD and/or ischemia/reperfusion mouse models. Reach out to our team to learn more about possibility of running other cardiovascular disease-related models.
TAC Mouse Model Sample Data

The TAC mouse model represents a gold standard surgical model to study efficacy of compounds on cardiac hypertrophy and associated heart failure (HF).
Mice who underwent TAC surgery show significant fibrosis (PSR) and cardiomyocyte hypertrophy (WGA) compared to sham-surgery TAC mice.
TAC Mouse Model Readouts
The People Behind Your Research
Yanick Fanton, PhD, Chief Scientific Officer
As Chief Science Officer at InnoSer, Yanick is responsible for all customer studies at InnoSer and takes care of the scientific and technical coordination.
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AAALAC Accreditation
InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
Animal Welfare
The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why InnoSer has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.
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