Duchenne Muscular Dystrophy DMD Mouse Model (mdx mouse)

Perform behavioral research studies to investigate your novel and innovative targeted Duchenne Muscular Dystrophy therapies using the DMD mouse model 

Home » Neurology CRO Services » Neuromuscular Disease – DMD Mouse Model (mdx mouse)

DMD Mouse Model Key Characteristics:

Duchenne muscular dystrophy (DMD) is a neuromuscular disorder characterized by progressive skeletal muscle weakening and wasting. To test the efficacy of novel therapies or disease-modifying treatments for DMD, multiple research models can be used. Out of these, the most commonly used is the mdx (B10. mdx) mouse model. The mdx mouse model closely recapitulates the human DMD pathophysiological characteristics due to an X-linked mutation in the gene that encodes dystrophin in the skeletal muscle membrane. 

Mdx mice show progressive cycles of skeletal muscle degeneration and regeneration that mimic human course of DMD, starting at approximately three weeks of age. As part of its preclinical research services, InnoSer performs efficacy studies in the mdx mouse model, focusing on functional readouts (skeletal muscle strength, motor function) as well as histopathology analyses (e.g., WGA, Sirius red, H&E) of skeletal muscle (regeneration, necrosis, hypertrophy). 

✓ The mdx mutation results in a termination codon of the dystrophin muscular dystrophy (Dmd) gene on the X chromosome.

✓ Mdx mice show robust muscle function impairments at a young age and display cognitive impairments under specific conditions (Remmelink et al. 2016; Engelbeen et al. 2021). 

European based preclinical CRO offering Infantile Epileptic Encaphalopathy Stxbp1 mouse models for drug development

Take advantage of InnoSer’s expertise, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with performing preclinical behavioural research services in in vivo models and help guide your decision on choosing the best model fit for your current research goals. 

InnoSer’s neurology expert team possesses relevant experience in working with multiple therapy types ranging from small molecules, peptides, enzymes, oligonucleotides, gene therapy (viral vectors – e.g.. AAVs) and immunotherapies (antibody/vaccine immunotherapies). 

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Belgian based preclinical neurology CRO mouse models

DMD Mouse Model Sample Data

DMD Mouse Model Readouts

Key Behavioral Readouts in the DMD Mouse Model


Test the efficacy of your treatments in the following battery of behavioural tests:

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Biological Readouts

Test the efficacy of your treatments with the following biological readouts: 
  
  • Histopathology (e.g., WGA, Sirius red, H&E etc.,) of skeletal muscle (regeneration, necrosis, hypertrophy) and heart tissue.

    Our Team’s Featured Publications

    • Remmelink, E., Aartsma-Rus, A., Smit, A. B., Verhage, M., Loos, M., & van Putten, M. (2016). Cognitive flexibility deficits in a mouse model for the absence of full-length dystrophin. Genes, brain, and behavior, 15(6), 558–567. https://doi.org/10.1111/gbb.12301 
    • Engelbeen, S., Aartsma-Rus, A., Koopmans, B., Loos, M., & van Putten, M. (2021). Assessment of Behavioral Characteristics With Procedures of Minimal Human Interference in the mdx Mouse Model for Duchenne Muscular Dystrophy. Frontiers in behavioral neuroscience, 14, 629043. https://doi.org/10.3389/fnbeh.2020.629043 

    The People Behind Your Research

    Thomas Vogels, PhD Neurology study director InnoSer

    Thomas Vogels, PhD, In Vivo Neurology Study Director

    Leads an expert team of scientists with vast experience in our Neurology models to help you choose the right model and guide your optimal study design. We provide the solution to accelerating your drug development.

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