Duchenne Muscular Dystrophy (mdx)

Perform behavioural research studies to investigate your novel and innovative targeted Duchenne Muscular Dystrophy therapies using the mdx mouse model

Home » Neurology Research Models and Services  » Neuromuscular Disease – Duchenne Muscular Dystrophy (mdx)
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder characterized by progressive muscle weakening and wasting. The disease is caused by nonsense or frame-shift mutations in the DMD gene, which encodes the muscle-related dystrophin protein. The most widely used DMD mouse model is the mdx mouse, which lacks functional dystrophin protein due to a point mutation.
Take advantage of InnoSer’s expertise, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with performing preclinical behavioural research services in in vivo models and help guide your decision on choosing the best model fit for your current research goals. 

Mdx mouse key model characteristics:

  • The mdx mutation results in a termination codon of the dystrophin muscular dystrophy (Dmd) gene on the X chromosome.
  • Crossing with C57BL/10ScSn required to generate relevant controls.
  • Mdx mice show robust muscle function impairments at a young age and display cognitive impairments under specific conditions (Remmelink et al. 2016; Engelbeen et al. 2021). 

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Belgian based preclinical neurology CRO mouse models

Key readouts

Test the efficacy of your treatments with the following commonly used behavioral tests:

Assess the efficacy of your treatments with the following biological readouts:

  • Histopathology

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