Duchenne Muscular Dystrophy (mdx)
Perform behavioural research studies to investigate your novel and innovative targeted Duchenne Muscular Dystrophy therapies using the mdx mouse model
Mdx mouse key model characteristics:
- The mdx mutation results in a termination codon of the dystrophin muscular dystrophy (Dmd) gene on the X chromosome.
- Crossing with C57BL/10ScSn required to generate relevant controls.
- Mdx mice show robust muscle function impairments at a young age and display cognitive impairments under specific conditions (Remmelink et al. 2016; Engelbeen et al. 2021).
Find the right model for you.
Compare our model capabilities and discover which of our neurology platforms suits your research needs
Test the efficacy of your treatments with the following commonly used behavioral tests:
- Grip strength test
- Catwalk gait analysis
- Rotarod test
- Wire hanging test
Assess the efficacy of your treatments with the following biological readouts:
The C57BL/10ScSnJ mdx mouse model for Duchenne Muscular Dystrophy shows significant muscle strength impairment
C57BL/10ScSnJ mdx mice show significant decreases in physical performance in the rotarod test in comparison to their WT litter mates at 4 weeks and 7 weeks of age (**P<0.001). The Rotarod is the golden standard for assessing motor performance and learning in mice. The mice are placed on a rotating rod, with increasing rotating speed. Motor performance is measured by the maximal RPM (rounds per minute) at which mice are able to keep up with the rotating rod. Motor learning can be assessed by training mice on the rod for several trials.
Related neuromuscular disease model options
Neurology Platform Overview
InnoSer offers a fee-for-service C-3PMP22 model to research novel therapies against Charcot Marie Tooth Type 1A.
Study novel interventions to improve physical performance in patients affected by muscular Spasticity using the Spa mouse model.
InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why InnoSer has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.
Need more information?
If you have any questions about how we can help accelerate your research,
then let us know