Duchenne Muscular Dystrophy (mdx)

Perform behavioural research studies to investigate your novel and innovative targeted Duchenne Muscular Dystrophy therapies using the mdx mouse model

Home » Neurology Research Models and Services  » Neuromuscular Disease – Duchenne Muscular Dystrophy (mdx)
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder characterized by progressive muscle weakening and wasting. The disease is caused by nonsense or frame-shift mutations in the DMD gene, which encodes the muscle-related dystrophin protein. The most widely used DMD mouse model is the mdx mouse, which lacks functional dystrophin protein due to a point mutation.
Take advantage of InnoSer’s expertise, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with performing preclinical behavioural research services in in vivo models and help guide your decision on choosing the best model fit for your current research goals. 

Mdx mouse key model characteristics:

  • The mdx mutation results in a termination codon of the dystrophin muscular dystrophy (Dmd) gene on the X chromosome.
  • Crossing with C57BL/10ScSn required to generate relevant controls.
  • Mdx mice show robust muscle function impairments at a young age and display cognitive impairments under specific conditions (Remmelink et al. 2016; Engelbeen et al. 2021). 

Find the right model for you.

Compare our model capabilities and discover which of our neurology platforms suits your research needs

Belgian based preclinical neurology CRO mouse models

Key readouts

Test the efficacy of your treatments with the following commonly used behavioral tests:

Assess the efficacy of your treatments with the following biological readouts:

  • Histopathology

Related neuromuscular disease model options

Neurology Platform Overview

Highly relevant neurology models to facilitate preclinical drug development.

CMT1A (C3-PMP22)

InnoSer offers a fee-for-service C-3PMP22 model to research novel therapies against Charcot Marie Tooth Type 1A. 

Spasticity

Study novel interventions to improve physical performance in patients affected by muscular Spasticity using the Spa mouse model.  

AAALAC Accreditation

InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.

AAALAC logo

Animal Welfare

The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why InnoSer has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.

Need more information?

If you have any questions about how we can help accelerate your research,

then let us know