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腹膜癌モデルにおける有効性評価のための腹膜癌指標
Peritoneal carcinomatosis (PC) represents an extreme form of metastatic cancer progression, commonly occurring in gastric, ovarian and colorectal cancers. Metastatic tumor models leading to PC help better understand the toxicities, timing and efficacy of novel...
Stxbp1欠損/存在てんかん性脳症モデルにおける新規抗てんかん薬の縦断的有効性評価
Previously, we have briefly introduced you to the Stxbp1 +/- mouse model of early infantile epileptic encephalopathies. Patients with a mutation in the STXBP1 gene (Syntaxin-binding protein 1, encoding the presynaptic protein Munc18-1) can receive a variety of...
アルツハイマー病およびパーキンソン病に対する薬剤の有効性をスクリーニングするためのトランスレーショナルなin vitroアッセイ
Modelling neurodegenerative disease using in vitro assays Neurodegenerative drug development is held back due to the lack of appropriate models that help accelerate the pace at which novel therapeutic candidates move through the drug development pipeline. As such, in...
野生型またはヒト化マウスにおける検証済み遅延型過敏反応アッセイ
Delayed-type hypersensitivity (DTH) in vivo assay represents a relatively quick and useful approach for evaluating the efficacy of potential immunomodulatory or immunosuppressive compounds. By challenging the cell-mediated immune response, you obtain valuable...
腎疾患モデルにおける経皮的GFR測定の妥当性検証
At InnoSer, we offer several readouts to assess the disease progression and the efficacy of novel targeted polycystic kidney disease (PKD) compounds. However, we understand that it remains a significant challenge to access crucial readouts that are recognized by...
事例研究：急性皮膚炎症・乾癬モデル
Performing efficacy studies using psoriasis models Psoriasis arises due to the dysregulation of the interplay between the innate and adaptive immune system together with other compartments such as epithelium, vasculature, and cutaneous nervous system. On the cellular...
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