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EEG-Aufzeichnung im Modell der epileptischen Enzephalopathie
September is STXBP1 disorders awareness month, an initiative aimed at raising awareness of STXBP1-related rare genetic disorders, such as epileptic encephalopathy. Although STXBP1-related disorders are rare; STXBP1 is the 5th most common cause of genetic forms of...
Kognitive Messgrößen zur Verbesserung der Wirksamkeitsprüfung von Stoffwechselwirkstoffen
While the so-called Western-style diets largely contribute to metabolic dysfunction observed in patients with overweight or obesity, type 2 diabetes mellitus and/or NASH, the current epidemiological evidence suggests that increased consumption of Western-style diets...
Durch Amyloid-beta verursachte Neuroinflammation in Alzheimer-Modellen
Amyloid and Tau mouse models recapitulate pathological processes found in patients with Alzheimer’s Disease (AD), including protein aggregation, neuroinflammation, neurodegeneration, and cognitive impairments. The key to understanding a therapeutic compound's effect...
Neuartiges translationales Messverfahren: EEG-Aufzeichnung auditorischer ereignisbezogener Potenziale in einem Modell des Fragile-X-Syndroms
Fragile X Syndrome Fragile X syndrome is caused by mutations of the FMR1 gene, leading to loss of functional fragile x mental retardation protein (FMRP). FXS is characterised by delays in neurodevelopmental milestones, autistic behaviour, anxiety, and cognitive...
Beschleunigung der Entwicklung von ALS-Medikamenten: Die von InnoSer angebotenen In-vivo-Modelle für die präklinische Forschung
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder lacking highly effective disease-modifying treatment or a cure. The often-heterogenous course of ALS underlines the need for modelling the different disease aspects in multiple, distinct models...
In-vitro- und In-vivo-Modelle der Parkinson-Krankheit: Einblicke in ihre Rolle in der präklinischen Arzneimittelentwicklung
Parkinson’s disease (PD) is a complex neurodegenerative disorder that affects millions of people worldwide. Different experimental models recapitulate distinct pathophysiological features of PD. Selecting the most appropriate model for a specific research question is...
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