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We move your identified hits forward into in vivo testing and lead optimization 

As a critical phase in your drug development journey, the hit to lead phase will determine which of your promising compounds will be characterized against your targets. With a lean ethos, InnoSer is dedicated to combining our expertise with your drug development goals in the most resource efficient way. During this phase of development, different analogues of your hit will be screened for the safest and most potent candidates to move through to optimization.

Our team is well-coordinated in providing a streamlined hit to lead transition while working closely with you on a meaningful and dedicated screening system to allow for efficient hit expansion. InnoSer provides robust and unbiased experimental design, methodology, analysis, interpretation, and reporting of results to support your journey into the Lead Optimization phase. 

私たちのアプローチ

We support your needs with customized solutions

Leveraging advancements in biotechnology we can harness in vitro and in vivo methods to support the development of new potential drug candidates. We support you with state-of-the-art facilities and advanced scientific expertise to make a difference and accelerate your drug development research.  

Our collaborative approach ensures that you see your hit compound’s properties improve to fulfill the necessary criteria moving into the Lead Optimization phase. Using multi-parametric methods we assess potency, selectivity, pharmacokinetic and physical properties enabling you to channel your resources into compounds that show promising signs of more uniform characteristics.

leiden facility for drug development

治療薬開発を推進するため、専門家と提携しましょう

当社のチームと協力し、精密かつ専門的な知見をもって、貴社の薬剤と治療標的の効果を評価します

医薬品開発段階投与経路

当社の能力

We offer many of these studies, with increasing sample sizes, all the way from early research leading to informed and translatable late preclinical research. 

We offer hit to lead development in a range of therapeutic fields and molecular entities using flexible and customizable hit to lead development steps. InnoSer provides functional assays, cell models, and in vivo methods to gain a robust overview of the strengths and optimization requirements of the investigational drug.  

Our in-house expertise lies in immuno-oncology, cardio-metabolic, neurology, and nephrology. However, our established network of connections provides our clients with proactive, timely, and comprehensive services to reach therapeutic success in a range of therapeutic areas. 

By providing a fully integrated solution, your project’s needs drive the services we provide and may feature one or more of the following services: 

In vitro pharmacology 

  • General efficacy 
  • Cell migration assay 
  • Tumor invasion assay 
  • Chemotaxis 
  • Angiogenesis assay 
  • Cellular phosphorylation 
  • Cell cycle assay (FACS) 
  • Endocrine disruption 
  • Dose finding in in-vitro disease models 
    • IC50, EC50 and AUC 
    • Medium Throughput 

In vitro ADME

  • Solubility 
  • Permeability 
  • Hepatic Microsome Stability 
  • CYP450 Inhibition Profiling 
  • Plasma Stability  
  • Plasma Protein Binding 
  • Cytotoxicity 
  • Biocompatibility & Skin Sensitization 
  • Genotoxicity 
  • Nephrotoxicity 
  • Hepatotoxicity 

Pharmacology 

  • Proof-of-Concept Studies 
  • Preliminary dose range finding (MTD) 

Toxicology 

  • 単回投与毒性 
  • 反復投与毒性 
  • 毒性動態学 

Biocompatibility

 

Pharmacometrics

InnoSer ロゴ ホワイト

医薬品開発パイプラインのナビゲーション

AAALAC認定

InnoSerはAAALAC認証を取得し、責任ある動物ケアと利用への取り組みを実証しています。AAALAC Internationalは、自主的な認証および評価プログラムを通じて科学における動物の適切な扱いを推進する非営利組織です。InnoSerのオランダおよびベルギー施設は、それぞれ2016年および2020年よりAAALAC認証を取得しています。AAALAC認証プログラムの詳細はこちらをご覧ください。

AAALACロゴ

動物福祉

3R原則は、政策や規制の変更から新技術・手法の開発と普及に至るまで、あらゆる分野に影響を及ぼします。このためInnoSerは、これらのプロセスに対する継続的な取り組みと監視を実施しています。当社が実践する手順は、動物実験の代替・削減・改善を最大限に実現し、研究および医薬品開発におけるこれらの原則への取り組みを促進します。

義務なし – 今すぐ始めよう

info@innoserlaboratories.com