3R’s: Replacement, Reduction, Refinement
変化をもたらすために努力する
Replace
With alternatives where ever possible
Reduce
The number of animals used
Refine
Experiments to minimize impact on animals
In vivo testing has been a valuable part of drug development and of the global fight against countless diseases. Now, thanks to innovative technologies, we are able to facilitate alternatives to animal experimentation and offer human specific preclinical research. At InnoSer, we also constantly re-evaluate and improve our protocols, ensure strict adherence to them, and remain transparent in our communication about these methods.
InnoSer’s 3R approach
In vitro models as alternatives
InnoSer strongly invests in a service portfolio of in vitro assays based on organoids and research and development programs such as organ-on-chip technology. Increasing the reliability of alternative preclinical screening models can not only promise the highest translation to clinical studies, but also reduce the number of animals needed.
Efficient colony management
InnoSer’s quality standards ensure efficient breeding of genetically altered rodents and facilitates the exchange of animals between institutes without the need for rederivation, both contributing to the reduction in number of animals. We also provide cryopreservation of rodent lines to decrease the need of rebreeding.
In vivo imaging for early decision making
Especially in long term studies, in vivo imaging proves to be extremely valuable in early determination of compound effectiveness. For example, in some of our oncology or PKD models, we can acquire mid-study data by non-invasive and real-time imaging. Based on the data we can focus only on a subset of lead compounds. This not only helps us refine animal use, but also manage our customer’s budget efficiently by cutting unnecessary costs.
Let’s get started on your project.
AAALAC認定
InnoSerはAAALAC認証を取得し、責任ある動物ケアと利用への取り組みを実証しています。AAALAC Internationalは、自主的な認証および評価プログラムを通じて科学における動物の適切な扱いを推進する非営利組織です。InnoSerのオランダおよびベルギー施設は、それぞれ2016年および2020年よりAAALAC認証を取得しています。AAALAC認証プログラムの詳細はこちらをご覧ください。
動物福祉
3R原則は、政策や規制の変更から新技術・手法の開発と普及に至るまで、あらゆる分野に影響を及ぼします。このためInnoSerは、これらのプロセスに対する継続的な取り組みと監視を実施しています。当社が実践する手順は、動物実験の代替・削減・改善を最大限に実現し、研究および医薬品開発におけるこれらの原則への取り組みを促進します。
info@innoserlaboratories.com