Angiotensin II-induced hypertension mouse model is the most widely used translational model of progressive hypertensive cardiac remodeling, left ventricular dysfunction and cardiac fibrosis induced by chronic Angiotensin II (AngII) infusion.  Chronic infusion of AngII, an endocrine hormone within the renin-angiotensin-aldosterone system (RAS), promotes vasoconstriction, cellular proliferation, hypertrophy, and fibrosis, leading to sustained hypertension, cardiac hypertrophy, and ultimately results in heart failure.  

The chronic hypertension mouse model closely mirrors human hypertensive heart disease, making it a highly translationally relevant research model for testing interventions aimed at reducing hypertension-driven cardiac remodeling and hypertension-induced heart failure. Due to the effects of AngII infusion on systemic blood pressure, this model is also suitable for studying hypertension-induced kidney injury and evaluating therapies for renal complications associated with chronic hypertension.