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Comment s'assurer que l'on travaille avec des modèles de recherche sur les maladies rénales pertinents sur le plan translationnel ?
Although multiple kidney disease models have been described in literature, not all of the models are well-characterized and suitable for preclinical research. To help accelerate the development of new drugs to improve the quality of life of patients living with a...
Indice du cancer péritonéal permettant d'évaluer l'efficacité dans un modèle de cancer péritonéal
Peritoneal carcinomatosis (PC) represents an extreme form of metastatic cancer progression, commonly occurring in gastric, ovarian and colorectal cancers. Metastatic tumor models leading to PC help better understand the toxicities, timing and efficacy of novel...
Longitudinal Efficacy Assessments of novel AEDs in the Stxbp1 +/- Epileptic Encephalopathy Model
Previously, we have briefly introduced you to the Stxbp1 +/- mouse model of early infantile epileptic encephalopathies. Patients with a mutation in the STXBP1 gene (Syntaxin-binding protein 1, encoding the presynaptic protein Munc18-1) can receive a variety of...
Tests in vitro translationnels visant à évaluer l'efficacité d'un médicament contre la maladie d'Alzheimer et la maladie de Parkinson
Modelling neurodegenerative disease using in vitro assays Neurodegenerative drug development is held back due to the lack of appropriate models that help accelerate the pace at which novel therapeutic candidates move through the drug development pipeline. As such, in...
Test validé d'hypersensibilité de type retardé chez des souris de type sauvage ou humanisées
Delayed-type hypersensitivity (DTH) in vivo assay represents a relatively quick and useful approach for evaluating the efficacy of potential immunomodulatory or immunosuppressive compounds. By challenging the cell-mediated immune response, you obtain valuable...
Mesure validée du débit de filtration glomérulaire (DFG) par voie transdermique dans des modèles de maladies rénales
At InnoSer, we offer several readouts to assess the disease progression and the efficacy of novel targeted polycystic kidney disease (PKD) compounds. However, we understand that it remains a significant challenge to access crucial readouts that are recognized by...
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