Metabolic disease models – MASH Mouse Model
Advance your MAFLD/MASH research with the diet-induced MASH NASH mouse model
MASH Mouse Model Characteristics
The MASH / NASH mouse model is a diet-induced mouse model leading to development of key hallmarks of (non-alcoholic fatty liver disease) NAFLD. Male mice (C57BL/6NTac) are conditioned on a modified Amylin liver NASH (AMLN) diet, containing 40% fat, 20% fructose and 2% cholesterol. This leads to the development of progressive obesity, fatty liver, liver inflammation, fibrosis, steatosis, hepatocyte ballooning, and activated stellate cells.
The diet-induced phenotype of NASH mice combined with InnoSer’s imaging, biochemical and histopathology capabilities offer you a robust platform for testing efficacy of novel, potential therapies targeting liver health, metabolic dysfunction, and inflammation. This model is ideal for studying NASH progression and evaluating potential therapeutic interventions, providing a range of histopathology and biochemical markers relevant to human NASH. Contact us today to discuss how this model can advance your research in NASH and NAFLD.
✓ A modified AMLN diet leads to progressive development of MAFLD/MASH (NASH/NAFLD) in C57BL/6NTac.
✓ Disease progression validated at InnoSer at different ages revealing progressive worsening of disease phenotype.
As a preclinical metabolic CRO, InnoSer’s team delivers you with a range of high-quality in vivo models for key metabolic diseases with different associated risk factors and aetiologias. This selection allows you to test therapeutic efficacy to prevent or reverse insulin resistance, pre-diabetes, obesity type 2 diabetes mellitus (T2DM), and/or MAFLD/MASH (NASH/NAFLD). To study metabolic disease-associated cardiovascular complications and cardiac dysfunction, InnoSer recommends the use of the Western diet-induced diabetic cardiomyopathy rat model. Reach out to our team to discuss the most suitable model to answer your research questions.
Uncover Diet-Induced Cognitive Deficits.
Explore key findings on how HF and HFCF diets impact cognition, with detailed data on memory performance and metabolic effects in mice. Download the poster for full insights.
MASH Mouse Model Sample Data
The diet-induced MASH NASH mouse model is suitable to obtain initial efficacy data in a physiologically induced model of MAFLD/MASH NASH/NAFLD.
Histopathology analyses reveal macrovascular steatosis (dotted line arrow), microvascular steatosis (bold arrow) and inflammatory cell clusters (within circles) at different ages of disease progression.
The diet-induced MASH NASH mouse model is suitable to obtain initial efficacy data in a physiologically induced model of MAFLD/MASH NASH/NAFLD.
Histopathological analyses reveal fibrosis at different ages of disease progression.
The diet-induced NASH mouse model is suitable to obtain initial efficacy data in a physiologically induced model of NASH/NAFLD.
The hepatic/Renal ratio, assessed by ultrasound, is increased in DIO C57BL6J MASH NASH animals indicating liver steatosis.
The diet-induced NASH mouse model is suitable to obtain initial efficacy data in a physiologically induced model of NASH/NAFLD.
Creatinine kinase is significantly higher in C57BL6J-NASH animals compared to healthy controls at different ages of disease progression.
The diet-induced NASH mouse model is suitable to obtain initial efficacy data in a physiologically induced model of NASH/NAFLD.
Liver function parameters (ALT, AST) are significantly higher in C57BL6J-MASH NASH animals compared to healthy controls at different ages of disease progression.
The diet-induced NASH mouse model is suitable to obtain initial efficacy data in a physiologically induced model of NASH/NAFLD.
Cholesterol levels are significantly higher in C57BL6J-NASH animals compared to healthy controls at different ages of disease progression.
The diet-induced NASH mouse model is suitable to obtain initial efficacy data in a physiologically induced model of NASH/NAFLD.
Blood glucose levels are higher in C57BL6J NASH mice compared to healthy controls (IPGTT).
MASH Mouse Model Readouts
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ヤニック・ファントン博士、最高科学責任者
イノサーの最高科学責任者として、ヤニックはイノサーにおける全ての顧客調査を担当し、科学的・技術的な調整業務を統括している。
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最新の心血管・代謝研究ニュース
InnoSerは、げっ歯類におけるゴールドスタンダードとなる心代謝疾患モデルを提供し、貴社の創薬候補の非臨床開発を最適化するためのカスタム研究を支援します。InnoSerの心血管分野における経験と専門知識をどのように活用できるか、詳細をご覧ください。
AAALAC認定
InnoSerはAAALAC認証を取得し、責任ある動物ケアと利用への取り組みを実証しています。AAALAC Internationalは、自主的な認証および評価プログラムを通じて科学における動物の適切な扱いを推進する非営利組織です。InnoSerのオランダおよびベルギー施設は、それぞれ2016年および2020年よりAAALAC認証を取得しています。AAALAC認証プログラムの詳細はこちらをご覧ください。
動物福祉
3R原則は、政策や規制の変更から新技術・手法の開発と普及に至るまで、あらゆる分野に影響を及ぼします。このためInnoSerは、これらのプロセスに対する継続的な取り組みと監視を実施しています。当社が実践する手順は、動物実験の代替・削減・改善を最大限に実現し、研究および医薬品開発におけるこれらの原則への取り組みを促進します。
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