In vitro immunoassays function as a critical tool to study various aspects of the complex immune system in the context of health and disease. Human and rodent immune cell lines and primary cells allow to evaluate the effect of investigational compounds on immune cell composition, activation status and polarisation, give a clear view on mechanisms of action, allow the identification of key biomarkers and allow early identification of potential immune toxicity. 

InnoSer offers preclinical research services using a wide range of commercially available cell lines and primary rodent (splenocytes, PBMCs) and human immune cell (T cells, B cells, macrophages, monocytes, PBMCs etc.,). Immunoassays using rodent or human cell lines are efficient, relatively inexpensive, have fast turn-around times, while primary cells allow to generate translational data taking into account disease mechanisms and patient variability. InnoSer’s immunoassay capabilities include macrophage polarization, T-cell activation and proliferation assays, cytokine release assays, tumor-killing assays, and mixed lymphocyte reaction assays. These examples listed can be used prior to or in conjunction with running in vivo studies in InnoSer’s mouse models of inflammatory and/or autoimmune diseases or our portfolio of immune-oncology rodent models.