September is STXBP1 disorders awareness month, an initiative aimed at raising awareness of STXBP1-related rare genetic disorders, such as epileptic encephalopathy. Although STXBP1-related disorders are rare; STXBP1 is the 5th most common cause of genetic forms of epilepsy¹. This raises the possibility to test both gene-targeting treatments and general anti-epileptic therapies in STXBP1 models. As seen below, the effect of such targeted treatments can be studied using the Stxbp1 +/- mouse model with robust and reproducible epileptic-like phenotypes.