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当社の最新の研究動向や企業情報をお届けする科学情報拠点です。
サルサレートがADPKDマウスモデルにおける疾患進行に及ぼす影響
サルサレートはNSAIDsに属するサリチル酸塩のプロドラッグ二量体であり、AMPKβ-1アイソフォームの薬剤結合ドメインとの直接的相互作用を通じてAMPKを活性化する。この特性から、サルサレートはADPKDにおける薬剤転用(ドラッグリポジショニング)の主要候補として浮上している。
腫瘍微小環境(TME)の多重免疫表現型解析
The use of preclinical orthotopic tumors to better recapitulate the tumor microenvironment (TME) Complex interactions between the cellular and structural components of the tumor microenvironment (TME) composed of tumor cells, fibroblasts, endothelial cells, immune...
脊髄損傷(SCI)マウスモデルの特性解析
Spinal cord injury (SCI) is a condition mainly resulting from traumatic injuries caused by falls, or (road traffic) accidents. Currently, many novel therapeutics ranging from small molecules, (stem) cell transplants to medical devices are evaluated for their efficacy...
Relevant pharmaco-EEG in vivo data (Baclofen, Fenfluramine)
Currently, preclinical neuroscience research calls for more translationally relevant biomarkers that help better predict clinical outcomes. Electrophysiological events recorded via electroencephalography (EEG) recordings, highly utilised in the clinic, arise as...
サルサレートは、ADPKDマウスモデルにおいて疾患の進行を抑制する
In this newsletter we present in-house validation data of Salsalate on disease progression in the ADPKD mouse model. One of key therapeutic strategies undertaken to provide new and efficacious treatments for ADPKD is targeting key signaling pathways that drive cystic...
関連する生体内研究およびin vitro免疫腫瘍学アッセイ
Drug efficacy in vivo studies At InnoSer, we frequently carry out in vivo efficacy studies in a range of preclinical models (patient-derived xenografts, syngeneic models, cell-line derived xenografts) complemented with readouts such immune cell profiling and...
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