Motor Function Tests – CatWalk™ Automated Gait Analysis System
The CatWalk™ automated gait analysis system is an advanced, high-throughput method for assessing gait patterns, motor coordination, and locomotor function in rodents
Key Research Model Applications of CatWalk™ Automated Gait Analysis System
The CatWalk™ automated gait analysis system (CatWalk™ XT, Noldus IT, The Netherlands) is a gait analysis system for quantitative assessment of gait and locomotion in mice. It is the most sophisticated system for quantification of a wide range of parameters related to footprints and gait in unforced moving animals. The CatWalk automated gait analysis system uses a transparent, illuminated walkway and high-speed cameras to capture a rodent’s walking behavior as it moves across the platform. Each paw print is automatically recorded, and the system generates detailed, real-time data on various gait parameters. The system is highly sensitive and capable of detecting even the slightest changes in locomotion and motor control, which are then analyzed using specialized software.
The CatWalk system is ideal for preclinical research where detailed quantification of walking behavior is crucial, offering reproducible data on locomotor deficits. It allows you to monitor changes in gait coordination, weight-bearing, stride patterns, and more, making it a valuable tool for assessing the efficacy of novel therapeutic compounds. As part of InnoSer’s innovative preclinical neurology CRO solutions, this motor function test is commonly used in combination with several other motor tests, such as Grip Strength test, Rotatod, or Balance Beam test. However, as each motor function test is unique, targeting different motor function skills in rodents, we recommend you discuss the most appropriate motor function behavioral test battery with our neurology study directors.
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CatWalk™ Automated Gait Analysis System Sample Data

The CatWalk™ gait analysis system enables quantification of a wide range of parameters related to footprint and gait in animals.

The CatWalk™ gait analysis system enables quantification of a wide range of parameters related to footprint and gait in animals.
Thy1-P301L mice show less aggressive pathophysiological development. At 6 months of age, subtle, but significant changes in gait and footprint size are observed on the Catwalk test indicating fine motor skills deficit. By 10 months or older, these mice show profound motor function deficits.

The CatWalk™ gait analysis system enables quantification of a wide range of parameters related to footprint and gait in animals.
WT mice support themselves with combination of diagonal paws, however this is significantly lower in the C3-PMP22 preclinical mouse model of Charcot Marie Tooth disease type 1A (CMT1A).

The CatWalk™ gait analysis system enables quantification of a wide range of parameters related to footprint and gait in animals.
6-month-old female hemizygous Prp-TDP43-Q331K (JAX #017933) tested in the CatWalk™ Gait Analysis show abnormal walking patterns (Stride length). Stride length (cm) refers to the distance between successive placements of the same paw.

The CatWalk™ gait analysis system enables quantification of a wide range of parameters related to footprint and gait in animals.
6-month-old female hemizygous Prp-TDP43-Q331K (JAX #017933) tested in the CatWalk™ Gait Analysis show abnormal walking patterns (Body speed). Body speed (cm/s) refers to the body movement speed between two consecutive steps of the same paw.

The CatWalk™ gait analysis system enables quantification of a wide range of parameters related to footprint and gait in animals.
6-month-old female hemizygous Prp-TDP43-Q331K (JAX #017933) tested in the CatWalk™ Gait Analysis show abnormal walking patterns (Body speed). Body speed (cm/s) refers to the body movement speed between two consecutive steps of the same paw.
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トーマス・フォーゲルズ博士、インビボ 神経学 研究責任者
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