3R’s: Replacement, Reduction, Refinement
Striving to make a difference
Replace
With alternatives where ever possible
Reduce
The number of animals used
Refine
Experiments to minimize impact on animals
In vivo testing has been a valuable part of drug development and of the global fight against countless diseases. Now, thanks to innovative technologies, we are able to facilitate alternatives to animal experimentation and offer human specific preclinical research. At InnoSer, we also constantly re-evaluate and improve our protocols, ensure strict adherence to them, and remain transparent in our communication about these methods.
InnoSer’s 3R approach
In vitro models as alternatives
InnoSer strongly invests in a service portfolio of in vitro assays based on organoids and research and development programs such as organ-on-chip technology. Increasing the reliability of alternative preclinical screening models can not only promise the highest translation to clinical studies, but also reduce the number of animals needed.
Efficient colony management
InnoSer’s quality standards ensure efficient breeding of genetically altered rodents and facilitates the exchange of animals between institutes without the need for rederivation, both contributing to the reduction in number of animals. We also provide cryopreservation of rodent lines to decrease the need of rebreeding.
In vivo imaging for early decision making
Especially in long term studies, in vivo imaging proves to be extremely valuable in early determination of compound effectiveness. For example, in some of our oncology or PKD models, we can acquire mid-study data by non-invasive and real-time imaging. Based on the data we can focus only on a subset of lead compounds. This not only helps us refine animal use, but also manage our customer’s budget efficiently by cutting unnecessary costs.
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Accréditation AAALAC
InnoSer a obtenu l'accréditation AAALAC, ce qui témoigne de notre engagement en faveur d'une prise en charge et d'une utilisation responsables des animaux. AAALAC International est une organisation à but non lucratif qui promeut le traitement sans cruauté des animaux dans le domaine scientifique par le biais de programmes volontaires d'accréditation et d'évaluation. Les sites d'InnoSer aux Pays-Bas et en Belgique sont accrédités par l'AAALAC depuis 2016 et 2020, respectivement. Pour en savoir plus sur le programme d'accréditation de l'AAALAC, cliquez ici.
Bien-être animal
Les « 3R » ont une incidence sur tous les domaines, depuis les changements politiques et réglementaires jusqu’au développement et à l’adoption de nouvelles technologies et approches. C’est pourquoi InnoSer s’engage en permanence à suivre ces processus. Les mesures que nous mettons en œuvre optimisent notre capacité à remplacer, réduire et perfectionner l’utilisation des animaux et facilitent notre engagement envers ces principes dans le cadre de la recherche et du développement de médicaments.
info@innoserlaboratories.com
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