InnoSer is acquiring a variety of preclinical imaging modalities for its Diepenbeek facility to offer its customers a comprehensive assessment of their models and compounds. Non-invasive and high-throughput kinetic assays with real-time readouts will improve screening efficiency and success rates. With additions expected in the near future, some initial modalities we provide are as below.

Ultrasound imaging

VisualSonics’ Vevo® 3100 LT combines high-resolution images with high frame-rates and advanced image processing. It also preserves and enhances image acquisition, whilst reducing noise and artifacts.

Ultrasound imaging is an ideal tool for quickly collecting anatomical, hemodynamic, and functional data in small animals. This makes it extremely useful for (immuno-) oncology applications, where volumetric analyses and the assessment of vascularization/perfusion allow tracking of the tumor’s progression, even in pre-palpable lesions.

In the context of InnoSer’s autosomal dominant polycystic kidney disease (ADPKD) screening platform, measuring kidney volume in vivo can be hugely beneficial in monitoring studies with a long duration. Ultrasound allows intermediate analysis of compound efficacy without the need to sacrifice animals, thereby reducing animal numbers according to the 3Rs. In addition, longitudinal follow-up allows us to interpret compound efficacy better throughout the study, saving our customer’s valuable time and resources. By reducing the risks associated with outsourcing these long projects, we make these models even more attractive.

Fluorescence and bioluminescence imaging

InnoSer also introduces the IVIS Spectrum that will provide high sensitivity, high throughput, and high-resolution in vivo fluorescence and bioluminescence imaging (BLI). By using 3D optical tomography, InnoSer will be able to offer monitoring of disease progression, cell trafficking and gene expression patterns in living animals. This can be especially useful for tracking tumorigenicity and tumor progression in mice inoculated with luciferase positive tumor cells. Also, it is a valuable tool for localizing and tracking cancer metastasis.

Other imaging modalities

InnoSer is also expanding its imaging capabilities with an ImageXpress Micro 4 system for high throughput in vitro imaging, as well as with an Incucyte® to explore in vitro biological changes in real-time.