Under normal conditions, neurofilaments, proteins that form the neuronal cytoskeleton, are released at low levels into the extracellular space. From there, they gradually enter the cerebrospinal fluid (CSF) and the bloodstream. Throughout life, levels of...
Earlier this year, we shared data from our phenotyping experiments showing TDP-43 mouse model pathophysiology, consistent with previously published findings in the same mouse model harboring the ALS-linked Q331K mutation in the TDP-43 gene (Watkins et al., 2021). Our...
The Meso-Scale Discovery (MSD) platform is a high-sensitivity, multiplex cytokine profiling analysis system, enabling you to simultaneously quantify multiple target cytokines, chemokines, antibodies, and growth factors from minute sample volumes (as low as 1 µL). By...
With several recent gene therapy approvals in space and more on the horizon, the field of rare genetic diseases is experiencing a transformative era. The field of rare genetic kidney diseases, including ADPKD remains no exception to this, with gene therapy emerging as...
With several recent gene therapy approvals in the CNS space and more on the horizon, the field of both genetic and neurodegenerative diseases is experiencing a transformative era. However, translating these therapies from preclinical research to clinical application...
This month we’re highlighting one of the most commonly used mouse models to study Duchenne Muscular Dystrophy (DMD) – the MDX mouse model B10.mdx), and explore how our advanced services can support your efficacy studies in DMD. The X-linked muscular dystrophy (MDX)...
