Ageing
Investigate relevant molecular compounds to promote increased human longevity and healthy ageing thanks to our experience with naturally aged mice
Aging is, however, a complex process in which all tissues in the body change over time. Given the multitude of potential causes of aging, it is challenging to find a good model system for this process. Therefore, the most holistic, agnostic, and straightforward method is to let wild-type mice age naturally over time.
Take advantage of InnoSer’s expertise in modelling the ageing pathology. Our in-house neurology experts are happy to help guide your decision on study design fit for your current research goals.
Aged mice model key characteristics:
- Aged mice are available up to 2 years of age.
- By 22 months of age, mice display profound changes in behaviour, different from changes seen in neurodegeneration models, such as decreased activity and velocity in the PhenoTyper™.
Find the right model for you.
Compare our model capabilities and discover which of our neurology platforms suits your research needs
Key readouts
Test the efficacy of your treatments in the following battery of cognitive behavioural tests:
- Spontaneous behaviour: PhenoTyper™
- IHC: senescence markers (p16INK4A; β-gal)
By 22 months of age, aged mice display profound changes in behaviour, different from changes seen in neurodegeneration models, such as decreased activity and velocity in the PhenoTyper™.
Mice display a variety of spontaneous behaviours in our automated home-cages (PhenoTyper™), which are tracked at high resolution with video cameras and do not require human intervention. During the first three days in the PhenoTyper™, our AHCODA analysis extracts 115 behavioural parameters (Loos et al. 2014; Loos et al. 2015). Tracking spontaneous behavior in the PhenoTyper™ allows rapid generation of a behavioral profile in novel mouse lines or sensitively studying therapeutic effects in disease models.
Related model options
Neurology Platform Overview
Alzheimer's Disease
Complimentary range of models and unique behavioural services that recapitulate key characteristics of Alzheimer’s Disease in vivo.
Parkinson's Disease
InnoSer offers unique behavioral services using in vivo models such as MPTP, 6-OHDA induced models, but also genetic (GBA, LRKK2) and alpha-synuclein (both transgenic and seeding).
AAALAC Accreditation
InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
Animal Welfare
The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why InnoSer has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.
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