Ageing – Naturally Aged Mouse Model
Investigate relevant compounds to promote increased human longevity and healthy ageing thanks to our experience with InnoSer’s naturally aged mouse model
Naturally Aged Mouse Model Key Characteristics
Ageing represents the accumulation of changes over time and generally increases the risk of a wide range of diseases, such as inflammatory and neurodegenerative diseases. Aging is, however, a complex process in which all tissues in the body change over time. Given the multitude of potential causes of aging, it is challenging to find a good model system for this process. Therefore, the most holistic, agnostic, and straightforward method is to let wild-type mice age naturally over time.
As part of our innovative preclinical research services in the field of neurology, InnoSer uses and has access to naturally aged mouse model cohorts of C57BL/6J (B6) mice that are up to 2 years of age. Similarly, you can perform efficacy studies in mouse models from InnoSer’s portfolio that show pathologies commonly associated with ageing such as of Aβ plaque pathology, tau pathology, and natural aging. Efficacy studies in the naturally aged mouse model can be complemented with various behavioral tests (focusing on cognition for example) as well as histopathology assessments (e.g., P16INK4A and β-galactosidase) to assess the degree of senescence.
✓ Aged mice are available up to 2 years of age.
✓ By 22 months of age, mice display profound changes in behavior, different from changes seen in neurodegeneration models, such as decreased activity and velocity in the PhenoTyper™.
Take advantage of InnoSer’s expertise in modeling the ageing pathology. Our in-house neurology experts are happy to help guide your decision on study design fit for your current research goals.
InnoSer’s neurology expert team possesses relevant experience in working with multiple therapy types ranging from small molecules, peptides, enzymes, oligonucleotides, gene therapy (viral vectors – e.g.. AAVs) and immunotherapies (antibody/vaccine immunotherapies).
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Naturally Aged Mouse Model Sample Data
By 22 months of age, aged mice display profound changes in behaviour, different from changes seen in neurodegeneration models, such as decreased activity and velocity in the PhenoTyper™.
Mice display a variety of spontaneous behaviours in our automated home-cages (PhenoTyper™), which are tracked at high resolution with video cameras and do not require human intervention. During the first three days in the PhenoTyper™, our AHCODA analysis extracts 115 behavioural parameters (Loos et al. 2014; Loos et al. 2015). Tracking spontaneous behavior in the PhenoTyper™ allows rapid generation of a behavioral profile in novel mouse lines or sensitively studying therapeutic effects in disease models.
Naturally Aged Mouse Model Readouts
Paramètres biologiques
Test the efficacy of your treatments with the following biological readouts:
- IHC: senescence markers (p16INK4A; β-gal)
Les personnes qui travaillent sur vos recherches
Sofie Carmans, docteure
Chercheur principal en neurologie
Thomas Vogels, docteur ès sciences
Chercheur principal en neurologie
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Accréditation AAALAC
InnoSer a obtenu l'accréditation AAALAC, ce qui témoigne de notre engagement en faveur d'une prise en charge et d'une utilisation responsables des animaux. AAALAC International est une organisation à but non lucratif qui promeut le traitement sans cruauté des animaux dans le domaine scientifique par le biais de programmes volontaires d'accréditation et d'évaluation. Notre accréditation est valable trois ans, y compris en 2023. Pour en savoir plus sur le programme d'accréditation AAALAC ici.
Bien-être animal
Les « 3R » ont une incidence sur tous les domaines, depuis les changements politiques et réglementaires jusqu’au développement et à l’adoption de nouvelles technologies et approches. C’est pourquoi InnoSer s’engage en permanence à suivre ces processus. Les mesures que nous mettons en œuvre optimisent notre capacité à remplacer, réduire et perfectionner l’utilisation des animaux et facilitent notre engagement envers ces principes dans le cadre de la recherche et du développement de médicaments.
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