Ageing represents the accumulation of changes over time and generally increases the risk of a wide range of diseases, such as inflammatory and neurodegenerative diseases. Aging is, however, a complex process in which all tissues in the body change over time. Given the multitude of potential causes of aging, it is challenging to find a good model system for this process. Therefore, the most holistic, agnostic, and straightforward method is to let wild-type mice age naturally over time.  

As part of our innovative preclinical research services in the field of neurology, InnoSer uses and has access to naturally aged mouse model cohorts of C57BL/6J (B6) mice that are up to 2 years of age. Similarly, you can perform efficacy studies in mouse models from InnoSer’s portfolio that show pathologies commonly associated with ageing such as of Aβ plaque pathology, tau pathology, and natural aging. Efficacy studies in the naturally aged mouse model can be complemented with various behavioral tests (focusing on cognition for example) as well as histopathology assessments (e.g., P16INK4A and β-galactosidase) to assess the degree of senescence.