Sensorimotor Tests – Auditory Event-related potentials (AERP)
Auditory event-related potentials (AERP) are neurophysiological correlates of sound perception and cognitive processes
Key Research Model Applications of Auditory Event-related Potentials (AERP)
Event related potentials (ERPs) are subtle changes in electrical activity generated in response to specific motor, sensory, or cognitive events. In clinical research, ERPs are often studied using an auditory oddball paradigm, where participants listen to a series of regular tones with occasional different or “odd” tones.
Clinical EEG recording in FXS patients has shown differences in event -related potential amplitudes. Such phenomenon is also observed in the Fmr1 KO mice, making this experiment a highly valued translational test for model characterization and intervention studies.
During an ERP recording session, multiple trials are provided with a 100 msec white noise stimulus (~70 dB), with 4-6 sec inter trial interval. Trials with movement artifacts (deducted from XYZ activity) are excluded, to generate a clean average AERP trace for the auditory cortex electrode.
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AERP Sample Data
Experimental setup for auditory event-related potential (AERP) EEG recording.
This experiment is conducted in a sound attenuating chamber (1). Mouse is implanted with a wireless EEG recording system that also collects body movement (XYZ activity) (2) and placed in a Plexiglas cylinder (3). A speaker is set up with adjustable volume and frequency to generate specific acoustic stimuli (4). A recorder is placed inside the chamber to record the sound (5), together with the infrared light synchronisation pulse generator (6) to help synchronize the acoustic stimuli with the recorded EEG signals. The figure shows a concept trace, based on internal data and literature.
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トーマス・フォーゲルズ博士、インビボ 神経学 研究責任者
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