Our Innovative Projects
PDX/O Oncology Platform
InnoSer has many collaborative projects with research groups from both academia and industry settings to develop novel technologies for use in preclinical settings. This includes a project executed in partnership with Vrije Universiteit Brussel and in close collaboration with Jessa Hospital in Hasselt, Belgium, and Leiden University Medical Center (LUMC, the Netherlands) that resulted in the development of an integrated PDXO drug screening platform. This platform consists of two complementary components, patient-derived xenografts (PDX) and patient-derived organoids (PDO), which are characterized in the same manner. Such models resemble the original patient-derived tumour both phenotypically and genetically. For this reason, one of the main advantages of such a platform is its predictive value in drug screening, as your compounds can be coherently tested both in vitro and in vivo, using the same starting parental material.
Many xenografts, organoids or combined models are already validated and currently available for compound testing. For other models, we are happy to collaborate and validate the platform with your compounds.
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Neurodevelopmental disorder mouse models at InnoSer — TSC, Rett & STXBP1
in this month's update, we invite you to explore recent developments in rare neurodevelopmental disorders associated with epilepsy and seizure phenotypes. We highlight emerging therapeutic approaches, discuss the importance of selecting translationally relevant...
Plasma NfL, p-tau217, or Aβ42/40: Which Alzheimer’s disease biomarkers should you include in your preclinical efficacy study?
A practical guide to preclinical Alzheimer’s disease biomarkers panel selection when you’re considering outsourcing to a specialist neurology CRO Biomarkers have transformed Alzheimer's disease clinical trials, enabling diagnosis confirmation for trial eligibility,...
Transgenic Amyloid, Tau, Seeding, or combined Amyloid/Tau pathology mouse models — which is the right one for your drug development program?
A practical guide to model selection when outsourcing your Alzheimer's disease efficacy study to a specialist neurology CRO Choosing the right Alzheimer's disease mouse model is one of the most consequential early decisions in a preclinical drug development program....
