Contextual Fear Conditioning
In contextual fear conditioning, mice learn to pair an unconditioned context with an aversive context. The freezing response of the mouse is monitored to assess the extent to which the unconditioned stimulus is paired with the aversive context. This test is a measure of both anxiety and cognition (learning and memory).
A fear conditioning box is used to measure contextual fear learning and memory.
The Fear conditioning test consists of 2 days. The first day (training), mice receive 1 mild electrical foot shock that is connected with a background condition (noise, scent). Day after receiving a mild electrical shock, mice are placed in the same box for 180 seconds and freezing duration is measured. Freezing duration is used as a measure of intact learning and memory performance.
A fear conditioning box is used to measure contextual fear learning and memory.
Stxbp1 +/- mice mimic cognitive impairments observed in epileptic patients that can be detected during a fear conditioning assay.
A fear conditioning box is used to measure contextual fear learning and memory.
WT mice spend on average more time freezing than Fmr1 KO mice, confirming that Fmr1 KO mice have a deficiency in recalling contextual fear memory (P=0.01).
Most commonly used in combination with:
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