Prior to starting the Novelty-Induced Hypophagia (NIH) test, mice are familiarized with a highly palatable snack placed into familiar metal food cup in the home-cage. On the test day, hypophagia is assessed by transferring the mice to a novel cage that contains the metal cup with the now familiar and highly palatable snack. In turn, NIH is measured by assessing the latency to start eating the snack. Commonly used inbred strains differ tremendously in NIH (Loos et al. 2009).
Although mice are highly motivated to eat from a familiarized highly palatable snack (a few crumbs of cream cracker), the novel environment induces anxiety-related-behaviour and as such a delay in consumption of the snack.
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