Motor function (Spontaneous Behaviour)

Mice display a variety of spontaneous behaviours in our PhenoTyper automated home-cages (Noldus IT, The Netherlands), which are tracked at high resolution with video cameras. The cages are equipped with a shelter compartment, on which mice climb during bouts of activity during the dark phase (Loos et al 2014; Loos 2015).

Mouse mutants with known motor function deficits, such as the SOD1 model of amyotrophic lateral sclerosis (ALS), show reduced or absent shelter climbing, an early detection of motor function deficits. Tracking of spontaneous behaviour in PhenoTyper cages is therefore a rapid and sensitive method for assessing motor function.

View our comprehensive range of sensitive and automated behavioural tests

Preclinical behavioral test for drug development

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