Motor Function Tests –Spontaneous Behavior
PhenoTyper home cages capture a multitude of spontaneous behaviors allowing you to perform detailed analyses of the efficacy of your novel compounds on motor function
Key Research Model Applications of Spontaneous Behavior Monitoring
Mice display a variety of spontaneous behaviours in our PhenoTyper automated home-cages (Noldus IT, The Netherlands), which are tracked at high resolution with video cameras. The cages are equipped with a shelter compartment, on which mice climb during bouts of activity during the dark phase (Loos et al 2014; Loos 2015).
Mouse mutants with known motor function deficits, such as the SOD1 model of amyotrophic lateral sclerosis (ALS), show reduced or absent shelter climbing, an early detection of motor function deficits. Tracking of spontaneous behaviour in PhenoTyper cages is therefore a rapid and sensitive method for assessing motor function.
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Spontaneous Behavior (Motor Function) Sample Data
Spontaneous behaviour relating to the motor function of mice in the automated home-cage (PhenoTyper™) is tracked at high resolution and analysed by AHCODA™.
Spontaneous behaviour relating to the motor function of mice in the automated home-cage (PhenoTyper™) is tracked at high resolution and analysed by AHCODA™.
SOD1 mutant mice show progressive behavioral changes in the PhenoTyper including a reduced frequency to climb on top of their shelter.
Spontaneous behaviour relating to the motor function of mice in the automated home-cage (PhenoTyper™) is tracked at high resolution and analysed by AHCODA™.
Cuprizone-treated mice show reductions in overall activity by measuring the distance moved in PhenoTyper™ cages.
Spontaneous behaviour relating to the motor function of mice in the automated home-cage (PhenoTyper™) is tracked at high resolution and analysed by AHCODA™.
Effect size plot showing the decrease in velocity and activity during the dark phase in ageing mice in comparison with neurodegeneration models.
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