Anxiety and Activity Tests –Fear Conditioning (FC)
Assess anxiety-related phenotypes
Key Research Model Applications of Fear Conditioning
Fear Conditioning (FC) is a widely used test to assess anxiety-related phenotypes in mice, as well as learning and memory. In the FC test, mice learn to associate an aversive stimulus with a neutral context or stimulus, resulting in a freezing response to the previously neutral stimulus.
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Fear Conditioning Sample Data
A fear conditioning box is used to measure contextual fear learning and memory.
The Fear conditioning test consists of 2 days. The first day (training), mice receive 1 mild electrical foot shock that is connected with a background condition (noise, scent). Day after receiving a mild electrical shock, mice are placed in the same box for 180 seconds and freezing duration is measured. Freezing duration is used as a measure of intact learning and memory performance.
A fear conditioning box is used to measure contextual fear learning and memory.
Stxbp1 +/- mice mimic cognitive impairments observed in epileptic patients that can be detected during a fear conditioning assay.
A fear conditioning box is used to measure contextual fear learning and memory.
WT mice spend on average more time freezing than Fmr1 KO mice, confirming that Fmr1 KO mice have a deficiency in recalling contextual fear memory (P=0.01).
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