Anxiety and Activity Tests –Elevated Plus Maze
Screen the efficacy of putative anxiolytic or anxiogenic compounds using the Elevated Plus Maze
Key Research Model Applications of Elevated Plus Maze
During the Elevated Plus Maze (EPM) mice are introduced into the maze which contains two open and two enclosed arms. In turn, the time that a mouse spends on the open arm is a measure of anxiety-related behaviour. To date, we’ve used this test for characterization of commonly used inbred strains (Loos et al. 2009) and in the Stxbp1 +/- epileptic encephalopathy model (Kovacevic et al. 2018).
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Elevated Plus Maze Sample Data
The elevated plus maze contains two open and two enclosed arms. Mice are reluctant to enter the open arms, which is a measure of anxiety-related behaviour.
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Thomas Vogels, PhD, In Vivo Neurology Study Director
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InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
Animal Welfare
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