Novel Object Recognition
The novel object recognition (NOR) test is used to test the memory for the shape, size, and location of objects. It capitalizes on the preference of mice for novelty, as this test measures how long the mouse interacts with a novel object. For the mouse to identify an object as novel, it has to remember that it has seen the object before. The novel object recognition test is therefore used as test of memory function.
Our scientists have previously shown impaired NOR performance in SNAP-25 heterozygous knockout mice, which is a risk gene for ADHD (Corradini et al. 2014).
In the Novel Object test, the preference of a mouse to explore a novel (N) object over a familiar (F) object is defined as the preference index (y-axis).
SNAP25 heterozygous mice display a lower preference index than control littermates, suggesting poor object recognition memory.