Cognitive Tests – Novel Object Recognition
The Novel Object Recognition test is a widely utilized behavioral assay to assess recognition memory and cognitive function in rodents
Key Research Model Applications of Novel Object Recognition
The novel object recognition (NOR) test is used to test the memory for the shape, size, and location of objects. It capitalizes on the preference of mice for novelty, as this test measures how long the mouse interacts with a novel object. For the mouse to identify an object as novel, it has to remember that it has seen the object before. The novel object recognition test is therefore used as a test of memory function. The duration of exploration serves as a measure of memory retention, with a greater exploration time directed toward the novel object indicating successful memory encoding.
Our scientists have previously shown impaired NOR performance in SNAP-25 heterozygous knockout mice, which is a risk gene for ADHD (Corradini et al. 2014).
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Novel Object Recognition Sample Data
In the Novel Object test, the preference of a mouse to explore a novel (N) object over a familiar (F) object is defined as the preference index (y-axis).
SNAP25 heterozygous mice display a lower preference index than control littermates, suggesting poor object recognition memory.
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