The Barnes Maze contains 24 holes whereby mice need to learn to locate an escape hole containing a home-cage by using visual cues that are placed around the maze. Following the initial spatial memory acquisition, a reversal paradigm can be used to measure the acquisition of new memory.  Administration of several cytotoxic chemotherapies was shown to lead to impaired performance in the Barnes Maze (Seigers et al. 2015). The Stxbp1 epileptic encephalopathy mouse model is impaired in the reversal learning protocol of this task (Kovacevic et al. 2018).

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Fragile X Syndrome

InnoSer offers unique preclinical behavioural research studies using Fmr1 knock-out (KO) mouse model. 

Infantile Epileptic Encephalopathy

InnoSer offers services using a unique Stxbp1 +/- mouse model.