Tau Seeding Mouse Models
Recapitulate the key structural features and spreading of Tau pathology in Alzheimer’s disease and other tauopathy patients with Tau Seeding Mouse Models
The histopathological hallmarks of Alzheimer’s disease (AD) are extracellular plaques composed of amyloid beta (Aβ) and intracellular inclusions of the protein Tau (neurofibrillary tangles). Tau pathology in AD and other Tauopathy patients (frontotemporal dementia (FTD), frontotemporal lobar degeneration, corticobasal degeneration, progressive supranuclear palsy, Pick’s disease) is strongly associated with neurodegeneration and clinical symptoms.
Injection of brain extract from Tauopathy patients in the mouse brain locally induces Tau pathology. The induced Tau pathology strongly mimics the lesions found in human AD and other tauopathy patients and accordingly spreads to other brain regions. InnoSer has extensive preclinical research experience with Tau seeding mouse models using AD patient-derived brain extracts in different Tau transgenic mice. Using the Tau seeding mouse models, brain extracts from other tauopathies can also be used, mimicking the unique features of Tau pathology in these diseases.
Take advantage of InnoSer’s preclinical research expertise in modelling Tau pathology, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with modelling Tau pathology in vivo and are happy to help guide your decision on study design fit for your current research goals.
InnoSer’s neurology expert team possesses relevant experience in working with multiple therapy types ranging from small molecules, peptides, enzymes, oligonucleotides, gene therapy (viral vectors – e.g.. AAVs) and immunotherapies (antibody/vaccine immunotherapies).
Tau seeding models key characteristics:
- Human brain-derived or recombinant Tau aggregates.
- Injections in transgenic or humanized Tau mice.
- Tau seeding in amyloid models allows simultaneous modelling of both AD pathologies.
- Injection of Tau seeds in transgenic Tau mice with FTD-related mutations leads to rapid and aggressive induction and propagation of Tau pathology.
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Key readouts in the Tau seeding mouse models
Test the efficacy of your treatments in the following battery of cognitive behavioural tests:
- MSD: Plasma, CSF and brain (phosphorylated Tau, cytokines, NF-L)
- (Digital) histopathology
- Immunohistochemistry (e.g., pTau, neuroinflammation.)
Example data in the Tau seeding mouse models
Progression of Tau pathology in the weeks after infusion of human Tau seeds into the hippocampus of Tau mice, as detected by AT8 fluorescent staining.
Human Tau seeds isolated from human AD brain tissue induce AT8-positive Tau cells in Tau mice.
The number of Tau inclusions and associated neuroinflammation or neurodegeneration can be quantified after immunohistochemical (IHC) staining of brain slices. The spreading of Tau pathology can be assessed by examining brain regions distant from the injection site. In addition, we measure (phosphorylated) Tau levels in the brain, cerebrospinal fluid, and blood using ultra-sensitive immunoassays (i.e., MSD, Simoa).
Related Alzheimer’s disease model options
Neurology Platform Overview
Transgenic Tau Mouse Models
InnoSer offers unique research services with several different transgenic tau models, which recapitulate the Tau neurofibrillary tangle pathology of AD.
APP Transgenic MIce
InnoSer offers preclinical research services with several different transgenic amyloid models, which recapitulate the plaque pathology of AD.