Cognitive and Automated Tests –CognitionWall™ Discrimination Learning
The CognitionWall™ Discrimination Learning test is a cutting-edge approach to assessing cognitive flexibility, decision-making, and learning ability in rodents
Key Research Model Applications of Cognition Wall™ Discrimination Learning
The CognitionWall™ is an advanced experimental setup designed to test discrimination learning, where rodents are trained to distinguish between two or more stimuli (e.g., visual, spatial, or tactile cues). The wall incorporates customizable compartments, barriers, or stimuli to present challenges requiring cognitive engagement, memory recall, and problem-solving. By assessing the animal’s ability to identify and respond correctly to specific cues, the test provides valuable insights into learning capacity, error rates, and adaptive behavior.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice (Remmelink et al. 2016), without the time-consuming handling of mice. Mice are rewarded with food when they choose to pass through one of the three entrances of the CognitionWall™. The rate at which a mouse gains preference for the entrance containing the food is used as a measure of discrimination learning. The discrimination learning is an automated home cage testing protocol that works with automatic cages (PhenoTyper™), a video monitoring system, and automatic data analysis system (AHCODA™). Partner with us to integrate CognitionWall™ Discrimination Learning into your studies.
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Cognition Wall™ Discrimination Learning Sample Data
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
The CognitionWall™ is a wall with three entrances in front of a food dispenser. Mice are rewarded with a food reward when they choose to pass through one of the three entrances. The rate at which a mouse gains a relative preference for the rewarded entrance is used as a measure of discrimination learning.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
Mouse models of AD show an impaired cognitive performance during the CognitionWall™ Discrimination learning. This deficit is already apparent at 12 weeks of age, before the appearance of plaques (~26 weeks). At 16 weeks, this deficit in discrimination learning can be rescued by an acute dose of the BACE1 inhibitor LY2886721.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
Mice injected with a low dose of MK-801 show robust cognitive deficits in the CognitionWall discrimination learning task in the PhenoTyper™.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
Fmr1 KO mice require more entries to reach a performance of 90% correct entries in the CognitionWal™ discrimination learning task in comparison with WT littermates, both 6 weeks of age as shown and at 12 weeks of age (not shown).
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