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Immunphänotypisierung zur Bewertung der Wirksamkeit neuartiger Immuntherapien
It is well-established that syngeneic mouse models represent a powerful tool to evaluate therapies that target the immune system. The key to understanding your immuno-modulatory compound's efficacy is to work with well-characterised models, with known growth kinetics...
EEG-Aufzeichnung auditorischer ereignisbezogener Potenziale bei Fmr1-KO-Mäusen
July is Fragile X Syndrome (FXS) Awareness month, a time dedicated to raising awareness about this rare genetic disorder, affecting thousands of individuals worldwide. We are deeply committed to accelerating the availability of targeted therapies to improve the lives...
EEG-Aufzeichnung im Modell der epileptischen Enzephalopathie
September is STXBP1 disorders awareness month, an initiative aimed at raising awareness of STXBP1-related rare genetic disorders, such as epileptic encephalopathy. Although STXBP1-related disorders are rare; STXBP1 is the 5th most common cause of genetic forms of...
Kognitive Messgrößen zur Verbesserung der Wirksamkeitsprüfung von Stoffwechselwirkstoffen
While the so-called Western-style diets largely contribute to metabolic dysfunction observed in patients with overweight or obesity, type 2 diabetes mellitus and/or NASH, the current epidemiological evidence suggests that increased consumption of Western-style diets...
Durch Amyloid-beta verursachte Neuroinflammation in Alzheimer-Modellen
Amyloid and Tau mouse models recapitulate pathological processes found in patients with Alzheimer’s Disease (AD), including protein aggregation, neuroinflammation, neurodegeneration, and cognitive impairments. The key to understanding a therapeutic compound's effect...
Neuartiges translationales Messverfahren: EEG-Aufzeichnung auditorischer ereignisbezogener Potenziale in einem Modell des Fragile-X-Syndroms
Fragile X Syndrome Fragile X syndrome is caused by mutations of the FMR1 gene, leading to loss of functional fragile x mental retardation protein (FMRP). FXS is characterised by delays in neurodevelopmental milestones, autistic behaviour, anxiety, and cognitive...
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