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L'immunophénotypage pour évaluer l'efficacité des nouvelles immunothérapies
It is well-established that syngeneic mouse models represent a powerful tool to evaluate therapies that target the immune system. The key to understanding your immuno-modulatory compound's efficacy is to work with well-characterised models, with known growth kinetics...
Enregistrement EEG des potentiels évoqués auditifs chez des souris Fmr1 KO
July is Fragile X Syndrome (FXS) Awareness month, a time dedicated to raising awareness about this rare genetic disorder, affecting thousands of individuals worldwide. We are deeply committed to accelerating the availability of targeted therapies to improve the lives...
Enregistrement EEG dans le modèle d'encéphalopathie épileptique
September is STXBP1 disorders awareness month, an initiative aimed at raising awareness of STXBP1-related rare genetic disorders, such as epileptic encephalopathy. Although STXBP1-related disorders are rare; STXBP1 is the 5th most common cause of genetic forms of...
Paramètres cognitifs visant à améliorer l'évaluation de l'efficacité des composés métaboliques
While the so-called Western-style diets largely contribute to metabolic dysfunction observed in patients with overweight or obesity, type 2 diabetes mellitus and/or NASH, the current epidemiological evidence suggests that increased consumption of Western-style diets...
Neuroinflammation induite par la bêta-amyloïde dans des modèles de la maladie d'Alzheimer
Amyloid and Tau mouse models recapitulate pathological processes found in patients with Alzheimer’s Disease (AD), including protein aggregation, neuroinflammation, neurodegeneration, and cognitive impairments. The key to understanding a therapeutic compound's effect...
Nouvelle méthode d'évaluation translationnelle : enregistrement EEG des potentiels auditifs liés à un événement dans un modèle du syndrome de l'X fragile
Fragile X Syndrome Fragile X syndrome is caused by mutations of the FMR1 gene, leading to loss of functional fragile x mental retardation protein (FMRP). FXS is characterised by delays in neurodevelopmental milestones, autistic behaviour, anxiety, and cognitive...
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