In vitro neurology assays are carried out using primary and/or immortalized rodent and/or human (co)-cultures to screen and identify candidate compounds for further lead selection via preclinical in vivo research. Cultures of cells found within the central nervous system (CNS) such as microglial and neuronal cells allow you to evaluate the mechanism of action and efficacy of your novel investigational compounds in an in vitro setting for neurotoxicity, neurodegeneration/neuroprotection or neuroinflammation assessment. 

InnoSer offers preclinical contract research services using a wide range of commercially available cell lines, as well as primary rodent cells. Leverage our validated in vitro neurodegeneration assays or partner with our scientists to set up and validate custom assays. After an initial disease model induction phase (using disease-associated proteins, protein aggregates. and chemical toxins), cell cultures are treated with your novel investigational compounds of choice to determine efficacy. In vitro neurodegenerative disease assays can be performed before or in conjunction with running in vivo preclinical studies (PK/PD profiling or efficacy studies in InnoSer’s mouse models of neurodegenerative diseases).