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Relevant pharmaco-EEG in vivo data (Baclofen, Fenfluramine)
Currently, preclinical neuroscience research calls for more translationally relevant biomarkers that help better predict clinical outcomes. Electrophysiological events recorded via electroencephalography (EEG) recordings, highly utilised in the clinic, arise as...
Salsalate verlangsamt das Fortschreiten der Erkrankung in einem ADPKD-Mausmodell
In this newsletter we present in-house validation data of Salsalate on disease progression in the ADPKD mouse model. One of key therapeutic strategies undertaken to provide new and efficacious treatments for ADPKD is targeting key signaling pathways that drive cystic...
Relevante In-vivo-Studien und In-vitro-Assays im Bereich der Immunonkologie
Drug efficacy in vivo studies At InnoSer, we frequently carry out in vivo efficacy studies in a range of preclinical models (patient-derived xenografts, syngeneic models, cell-line derived xenografts) complemented with readouts such immune cell profiling and...
Beurteilung des Krankheitsverlaufs im ADPKD-Mausmodell
A significant challenge in the ADPKD research field is demonstrating efficacy of novel compounds in preclinical research models using clinically relevant endpoints. To date, total kidney volume (TKV) is the only FDA and EMA-approved imaging biomarker that is used as a...
InnoSer partners with CR2O to offer an integrated drug discovery to clinical trials pipeline.
InnoSer partners with CR2O to offer an integrated drug discovery to clinical trials pipeline. Researchers benefit from a comprehensive service offering, spanning early-stage discovery to phase I-IV trials, with meticulous planning and access to specialized services,...
Die Anwendung der Biolumineszenz-Bildgebung in der präklinischen onkologischen Forschung und darüber hinaus
Introduction into the power of bioluminescence imaging Bioluminescence imaging (further referred to as BLI in this article) is an in vivo imaging technique that allows non-invasive longitudinal monitoring of in vivo processes, commonly applied in preclinical oncology...
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