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Translationale In-vitro-Assays zur Überprüfung der Wirksamkeit von Arzneimitteln bei Alzheimer und Parkinson
Modelling neurodegenerative disease using in vitro assays Neurodegenerative drug development is held back due to the lack of appropriate models that help accelerate the pace at which novel therapeutic candidates move through the drug development pipeline. As such, in...
Validierter Test zur Bestimmung der verzögerten Überempfindlichkeit bei Wildtyp- oder humanisierten Mäusen
Delayed-type hypersensitivity (DTH) in vivo assay represents a relatively quick and useful approach for evaluating the efficacy of potential immunomodulatory or immunosuppressive compounds. By challenging the cell-mediated immune response, you obtain valuable...
Validierte transdermale GFR-Messung in Modellen für Nierenerkrankungen
At InnoSer, we offer several readouts to assess the disease progression and the efficacy of novel targeted polycystic kidney disease (PKD) compounds. However, we understand that it remains a significant challenge to access crucial readouts that are recognized by...
Fallstudie: Modell einer akuten Hautentzündung (Psoriasis)
Performing efficacy studies using psoriasis models Psoriasis arises due to the dysregulation of the interplay between the innate and adaptive immune system together with other compartments such as epithelium, vasculature, and cutaneous nervous system. On the cellular...
Immunphänotypisierung zur Bewertung der Wirksamkeit neuartiger Immuntherapien
It is well-established that syngeneic mouse models represent a powerful tool to evaluate therapies that target the immune system. The key to understanding your immuno-modulatory compound's efficacy is to work with well-characterised models, with known growth kinetics...
EEG-Aufzeichnung auditorischer ereignisbezogener Potenziale bei Fmr1-KO-Mäusen
July is Fragile X Syndrome (FXS) Awareness month, a time dedicated to raising awareness about this rare genetic disorder, affecting thousands of individuals worldwide. We are deeply committed to accelerating the availability of targeted therapies to improve the lives...
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