Humanized mouse models for immuno-oncology research are immunodeficient mice, with reconstituted human immune system (e.g., via PBMCs or CD34+ hematopoietic stem cells) co-engrafted with human tumors using either human cell lines or patient-derived tumor samples. Alternatively, transgenic knock-in humanized mouse models carrying human genes (such as human PD-1) are also available. This approach allows you to test your novel therapies with distinct patient tumor tissues and the human immune system of your choosing as the most accurate and specific representation of the patient tumor and immune system.  

Using patient-derived xenografts or cell line-derived xenografts, human tumor cells or tissues are implanted in mice that feature an intact humanized immune system, representing a powerful tool for immuno-oncology research. Compared to other models where immunodeficient mice are used, humanized mice represent more advanced models, with InnoSer’s expert recommendation to be used in the advanced stages of your preclinical research.