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L'utilisation de l'indice kystique dans le modèle murin de la PKD autosomique dominante
The kidneys of autosomal dominant polycystic kidney disease (ADPKD) patients progressively enlarge due to the formation and expansion of fluid-filled cysts. However, currently there is no available therapy for ADPKD patients that targets the growth of cysts,...
L'importance d'intégrer des mesures translationnelles de la fonction rénale dans vos recherches précliniques : la mesure transdermique du débit de filtration glomérulaire (DFG)
Preclinical Nephrology Research Preclinical studies aiming to assess kidney function in animal models of kidney disease or in response to a test compound have traditionally included readouts such as serum creatinine and blood urea nitrogen (BUN). However, the use of...
Modulateurs de l'eIF2B dans la « matière blanche en voie de disparition »
Vanishing White Matter (VWM) disease is a rare and fatal leukodystrophy, caused by recessive mutations in the five genes encoding the protein complex eukaryotic translation initiation factor 2B (eIF2B). eIF2B plays a crucial role in initiating and regulating the...
Comment s'assurer que l'on travaille avec des modèles de recherche sur les maladies rénales pertinents sur le plan translationnel ?
Although multiple kidney disease models have been described in literature, not all of the models are well-characterized and suitable for preclinical research. To help accelerate the development of new drugs to improve the quality of life of patients living with a...
Indice du cancer péritonéal permettant d'évaluer l'efficacité dans un modèle de cancer péritonéal
Peritoneal carcinomatosis (PC) represents an extreme form of metastatic cancer progression, commonly occurring in gastric, ovarian and colorectal cancers. Metastatic tumor models leading to PC help better understand the toxicities, timing and efficacy of novel...
Longitudinal Efficacy Assessments of novel AEDs in the Stxbp1 +/- Epileptic Encephalopathy Model
Previously, we have briefly introduced you to the Stxbp1 +/- mouse model of early infantile epileptic encephalopathies. Patients with a mutation in the STXBP1 gene (Syntaxin-binding protein 1, encoding the presynaptic protein Munc18-1) can receive a variety of...
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