The CognitionWall™ Discrimination Learning test setup challenges rodents to first learn an initial rule or association (e.g., choosing a specific visual cue or pathway for a reward) and then adapt when the rule changes (Reversal Learning). During the reversal phase, the previously correct choice becomes incorrect, and rodents must adjust their behavior to succeed. By tracking the animal’s ability to suppress prior learning and adapt to the new rule, this test provides insights into cognitive flexibility. 

The CognitionWall™ reversal learning test involves rewarding the mice with food when they choose to pass through one of the switched three entrances, representing reversal. The rate at which the mouse gains a relative preference for the newly rewarded entrance is used as a measure of reversal learning.