Cognitive and Automated Tests –CognitionWall™ Discrimination Learning
The CognitionWall™ Discrimination Learning test is a cutting-edge approach to assessing cognitive flexibility, decision-making, and learning ability in rodents
Key Research Model Applications of Cognition Wall™ Discrimination Learning
The CognitionWall™ is an advanced experimental setup designed to test discrimination learning, where rodents are trained to distinguish between two or more stimuli (e.g., visual, spatial, or tactile cues). The wall incorporates customizable compartments, barriers, or stimuli to present challenges requiring cognitive engagement, memory recall, and problem-solving. By assessing the animal’s ability to identify and respond correctly to specific cues, the test provides valuable insights into learning capacity, error rates, and adaptive behavior.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice (Remmelink et al. 2016), without the time-consuming handling of mice. Mice are rewarded with food when they choose to pass through one of the three entrances of the CognitionWall™. The rate at which a mouse gains preference for the entrance containing the food is used as a measure of discrimination learning. The discrimination learning is an automated home cage testing protocol that works with automatic cages (PhenoTyper™), a video monitoring system, and automatic data analysis system (AHCODA™). Partner with us to integrate CognitionWall™ Discrimination Learning into your studies.
Les tests comportementaux chez la souris en toute simplicité.
Découvrez notre vaste gamme de tests comportementaux et cognitifs validés et sur mesure destinés aux rongeurs, conçus pour faire progresser vos recherches.
Mur de la cognition™ Apprentissage de la discrimination Exemples de données
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
The CognitionWall™ is a wall with three entrances in front of a food dispenser. Mice are rewarded with a food reward when they choose to pass through one of the three entrances. The rate at which a mouse gains a relative preference for the rewarded entrance is used as a measure of discrimination learning.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
Mouse models of AD show an impaired cognitive performance during the CognitionWall™ Discrimination learning. This deficit is already apparent at 12 weeks of age, before the appearance of plaques (~26 weeks). At 16 weeks, this deficit in discrimination learning can be rescued by an acute dose of the BACE1 inhibitor LY2886721.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
Mice injected with a low dose of MK-801 show robust cognitive deficits in the CognitionWall discrimination learning task in the PhenoTyper™.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
Fmr1 KO mice require more entries to reach a performance of 90% correct entries in the CognitionWal™ discrimination learning task in comparison with WT littermates, both 6 weeks of age as shown and at 12 weeks of age (not shown).
Les personnes qui travaillent sur vos recherches
Thomas Vogels, docteur en sciences, In Vivo Neurologie Directeur d'étude
Dirige une équipe d'experts scientifiques possédant une vaste expérience de nos modèles de neurologie afin de vous aider à choisir le modèle le plus adapté et vous guide dans votre conception optimale conception d’étude. Nous vous proposons la solution pour accélérerele rythme le développement de vos médicaments.
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Accréditation AAALAC
InnoSer a obtenu l'accréditation AAALAC, ce qui témoigne de notre engagement en faveur d'une prise en charge et d'une utilisation responsables des animaux. AAALAC International est une organisation à but non lucratif qui promeut le traitement sans cruauté des animaux dans le domaine scientifique par le biais de programmes volontaires d'accréditation et d'évaluation. Les sites d'InnoSer aux Pays-Bas et en Belgique sont accrédités par l'AAALAC depuis 2016 et 2020, respectivement. Pour en savoir plus sur le programme d'accréditation de l'AAALAC, cliquez ici.
Bien-être animal
Les « 3R » ont une incidence sur tous les domaines, depuis les changements politiques et réglementaires jusqu’au développement et à l’adoption de nouvelles technologies et approches. C’est pourquoi InnoSer s’engage en permanence à suivre ces processus. Les mesures que nous mettons en œuvre optimisent notre capacité à remplacer, réduire et perfectionner l’utilisation des animaux et facilitent notre engagement envers ces principes dans le cadre de la recherche et du développement de médicaments.
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