News, Resources, Updates
A scientific hub to keep you informed about our latest research and company updates.
HTT1a and HTTexon1 Huntington’s disease – A new therapeutic target explored in the zQ175 mouse model
We will build upon our experience with mutant huntingtin (mHTT) in the extensively profiled zQ175 knock-in mouse model of Huntington’s Disease, and highlight a new point of interest for therapeutic intervention discussed in the literature: the HTT1a mRNA transcript,...
Personalized Lymphoma CDX mouse models for preclinical oncology
In recent studies, we established and validated two new human lymphoma cell‑line–derived xenograft (CDX) models, generated from the OCI‑Ly19 (diffuse large B‑cell lymphoma, DLBCL) and REC‑1 (mantle cell lymphoma) cell lines. These models were developed in strategic...
Modelling TDP-43 proteinopathy and motor neuron disease pathophysiology in mouse models
Transactivating response region (TAR) DNA binding protein (TDP-43) is a nuclear protein involved in regulating RNA transcription, splicing, trafficking, and microRNA biogenesis. TDP-43 is a major component of neuronal and glial inclusions in both the brain and the...
InnoSer and Carthera Launch Preclinical Access to the SonoCloud® Ultrasound Platform for CNS Drug Delivery
Researchers developing central nervous system (CNS)-targeted therapies can now leverage Carthera’s SonoCloud® ultrasound-mediated drug delivery platform, helping inform and enhance preclinical development strategies for novel therapeutics. Diepenbeek, Belgium, and...
Neurofilament light chain (NfL) in plasma and CSF: A translational biomarker for neurodegeneration in InnoSer’s neurology mouse models
Under normal conditions, neurofilaments, proteins that form the neuronal cytoskeleton, are released at low levels into the extracellular space. From there, they gradually enter the cerebrospinal fluid (CSF) and the bloodstream. Throughout life, levels of...
New insights into TDP-43 mouse model pathophysiology
Earlier this year, we shared data from our phenotyping experiments showing TDP-43 mouse model pathophysiology, consistent with previously published findings in the same mouse model harboring the ALS-linked Q331K mutation in the TDP-43 gene (Watkins et al., 2021). Our...
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