InnoSer News
Glomerular filtration rate (GFR) in the ADPKD mouse model
Preclinical studies aiming to assess kidney function traditionally include readouts such as serum creatinine and/or blood urea nitrogen (BUN). However, the use of readouts that are more clinically relevant such as glomerular filtration rate (GFR) is highly encouraged,...
Characterization of a transgenic TDP-43 Mouse Model
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of upper and lower motoneurons. This leads to brain degeneration and muscle denervation, resulting in extensive muscle atrophy and functional motor impairments....
Effect of Salsalate on disease progression in the ADPKD Mouse Model
Salsalate is a pro-drug dimer of salicylate belonging to the family of NSAIDs, activating AMPK through direct interactions with the drug-binding domain of the AMPK beta-1 isoform. As such, Salsalate arises as a key candidate for drug repurposing in ADPKD. To...
Tumor microenvironment (TME) multiplex immunophenotyping analyses
The use of preclinical orthotopic tumors to better recapitulate the tumor microenvironment (TME) Complex interactions between the cellular and structural components of the tumor microenvironment (TME) composed of tumor cells, fibroblasts, endothelial cells, immune...
Characterization of a Spinal Cord Injury (SCI) Mouse Model
Spinal cord injury (SCI) is a condition mainly resulting from traumatic injuries caused by falls, or (road traffic) accidents. Currently, many novel therapeutics ranging from small molecules, (stem) cell transplants to medical devices are evaluated for their efficacy...
Relevant pharmaco-EEG in vivo data (Baclofen, Fenfluramine)
Currently, preclinical neuroscience research calls for more translationally relevant biomarkers that help better predict clinical outcomes. Electrophysiological events recorded via electroencephalography (EEG) recordings, highly utilised in the clinic, arise as...
Salsalate ameliorates disease progression in ADPKD mouse model
In this newsletter we present in-house validation data of Salsalate on disease progression in the ADPKD mouse model. One of key therapeutic strategies undertaken to provide new and efficacious treatments for ADPKD is targeting key signaling pathways that drive cystic...
Relevant in vivo studies and in vitro immuno-oncology assays
Drug efficacy in vivo studies At InnoSer, we frequently carry out in vivo efficacy studies in a range of preclinical models (patient-derived xenografts, syngeneic models, cell-line derived xenografts) complemented with readouts such immune cell profiling and...
Assessment of Disease Progression in the ADPKD Mouse Model
A significant challenge in the ADPKD research field is demonstrating efficacy of novel compounds in preclinical research models using clinically relevant endpoints. To date, total kidney volume (TKV) is the only FDA and EMA-approved imaging biomarker that is used as a...
InnoSer partners with CR2O to offer an integrated drug discovery to clinical trials pipeline.
InnoSer partners with CR2O to offer an integrated drug discovery to clinical trials pipeline. Researchers benefit from a comprehensive service offering, spanning early-stage discovery to phase I-IV trials, with meticulous planning and access to specialized services,...
The Application of Bioluminescence Imaging in Preclinical Oncology Research and Beyond
Introduction into the power of bioluminescence imaging Bioluminescence imaging (further referred to as BLI in this article) is an in vivo imaging technique that allows non-invasive longitudinal monitoring of in vivo processes, commonly applied in preclinical oncology...
Latest cardiovascular and metabolic research news
InnoSer offers a selection of gold standard cardio-metabolic disease models in rodents, supporting custom studies to optimize the preclinical development of your drug candidates. Learn more about you can leverage InnoSer’s experience and expertise in the...