Test your novel Parkinson’s disease therapeutics aimed at targeting intracellular lysosomal pathways in the LRRK2 model
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which encodes a kinase with a multitude of cellular functions (e.g., lysosomal function), are associated with PD. In line, the inhibition of LRRK2 is being increasingly pursued as a therapeutic strategy in PD treatment.
Take advantage of InnoSer’s expertise in modelling PD pathology, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with modelling LRRK2 pathology in vivo and are happy to help guide your decision on a study design fit for your current research goals.
LRRK2 model key model characteristics:
- Transgenic mouse model with human LRRK2 with disease associated mutations (e.g., G2019S).
- Combination of LRRK2 models with alpha-synuclein models (e.g., seeding).
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Test the efficacy of your treatments with the following biological readouts:
- MSD (e.g. LRRK2 levels)
- Immunofluorescence and FISH
Related Parkinson’s Disease model options
MPTP Induced PD Models
Transgenic Alpha-Synuclein Models
Targeting intracellular lysosomal pathways using in vivo models with GBA-associated mutations.
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